猪肾远端小管对铝的排泄

Aluminium excretion by the distal tubule of the pig kidney.

作者信息

Monteagudo F S, Isaacson L C, Wilson G, Hickman R, Folb P I

机构信息

Department of Pharmacology, University of Cape Town Medical School, Republic of South Africa.

出版信息

Nephron. 1988;49(3):245-50. doi: 10.1159/000185064.

DOI:10.1159/000185064

PMID:3398986

Abstract

The renal tubular handling of aluminium was investigated, using the stop-flow method, in 8 pigs (2 controls, 2 'dose range', and 4 experimental). Aluminium was measured by graphite furnace atomic absorption spectroscopy. In 11 stop-flow studies in the 4 experimental pigs, intratubular aluminium concentrations, corrected for water reabsorption, peaked in the distal nephron. Interrupted stop-flow revealed that aluminium was excreted into the tubule at this site. The aluminium excretion site was situated at or close to the sites of maximal calcium and sodium reabsorption. Aluminium excretion occurs in the distal tubule of the pig kidney.

摘要

采用停流法对8头猪（2头对照猪、2头“剂量范围”猪和4头实验猪）的肾小管对铝的处理情况进行了研究。通过石墨炉原子吸收光谱法测定铝含量。在对4头实验猪进行的11次停流研究中，经水重吸收校正后的肾小管内铝浓度在远端肾单位达到峰值。间断停流显示铝在该部位排入肾小管。铝的排泄部位位于最大钙和钠重吸收部位或其附近。猪肾远端小管存在铝排泄现象。