Key Laboratory of Brain, Cognition and Education Sciences, South China Normal University, Ministry of Education, China; School of Psychology, South China Normal University, Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China.
Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
J Psychiatr Res. 2021 Jun;138:560-568. doi: 10.1016/j.jpsychires.2021.04.041. Epub 2021 Apr 29.
Callous unemotional (CU) traits differentiate subtypes of conduct disorder (CD). It has been suggested that CU traits may be related to topographical irregularities that hinder information integration. To date, there is limited evidence of whether CU traits may be associated with abnormal brain topology. In this study, 43 CD boys with high and low CU trait (CD-HCU, CD-LCU), and 46 healthy controls (HCs) were subjected to resting-state functional magnetic resonance imaging to investigate how CU trait level and conduct problems may be reflected in topological organization. Brain functional networks were constructed and network/nodal properties, including small-world properties and network/nodal efficiency, were calculated. Topological analysis revealed that, compared with HCs, CD-HCU group were characterized by decreased small-worldness (σ), decreased global efficiency, and increased path length (λ). These variables were similar between the CD-LCU and HC groups. Self-reported CU traits in CD patients correlated negatively with global efficiency and positively with λ. Regional analysis revealed diminished nodal efficiency in the right amygdala in the CD-HCU group compared with HCs. The present results suggest that disrupted global efficiency, together with a regional abnormality affecting the amygdala, may contribute to abnormal information processing and integration in adolescents with CD and high CU traits.
冷酷无情（CU）特征可区分品行障碍（CD）的亚型。有人认为 CU 特征可能与阻碍信息整合的地形不规则有关。迄今为止，关于 CU 特征是否与异常脑拓扑结构有关的证据有限。在这项研究中，对 43 名 CD 男孩（高 CU 特质 CD-HCU 和低 CU 特质 CD-LCU）和 46 名健康对照（HCs）进行了静息态功能磁共振成像，以探讨 CU 特质水平和行为问题如何反映拓扑组织。构建脑功能网络，并计算网络/节点属性，包括小世界属性和网络/节点效率。拓扑分析显示，与 HCs 相比，CD-HCU 组的小世界特性（σ）降低，全局效率降低，路径长度（λ）增加。CD-LCU 组与 HC 组之间这些变量相似。CD 患者自我报告的 CU 特征与全局效率呈负相关，与 λ 呈正相关。区域分析显示，与 HCs 相比，CD-HCU 组右侧杏仁核的节点效率降低。本研究结果表明，全局效率的破坏以及影响杏仁核的局部异常，可能导致 CD 伴有高 CU 特质的青少年异常信息处理和整合。
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