College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, People's Republic of China; Key Laboratory of Food Macromolecular Resources Processing Technology Research (Zhejiang University of Technology), China National Light Industry, People's Republic of China.
College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, People's Republic of China.
Food Res Int. 2021 May;143:110237. doi: 10.1016/j.foodres.2021.110237. Epub 2021 Feb 26.
In this study, stigmasterol was nanoencapsulated in soy protein isolate -pectin-based nanodispersions. Based on the particle size and zeta-potential, the optimal pectin/SPI ratio of stigmasterol nanodispersion was determined to be 1:10. At this ratio, nanodispersions was manufactured with an average particle size of 477 ± 33 nm, an encapsulation efficiency of 89.37%, and a loading amount of 17.87%. The physical properties and morphology of the nanodispersion were investigated. Fourier transform infrared spectroscopy and differential scanning calorimetry analysis revealed that stigmasterol was loaded in nanodispersions successfully. The pectin, which was used to stable nanodispersion, could restrict the release of stigmasterol in the simulated gastric fluid. This experiment indicated that the presence of pectin can improve the stability of the nanodispersion and can be used to achieve controlled release of bioactive compounds.
在这项研究中，豆固醇被纳米封装在大豆分离蛋白-果胶基纳米分散体中。基于粒径和 Zeta 电位，确定了豆固醇纳米分散体的最佳果胶/SPI 比为 1:10。在这个比例下，纳米分散体的平均粒径为 477 ± 33nm，包封效率为 89.37%，载药量为 17.87%。对纳米分散体的物理性质和形态进行了研究。傅里叶变换红外光谱和差示扫描量热法分析表明，豆固醇已成功加载于纳米分散体中。用于稳定纳米分散体的果胶可以限制豆固醇在模拟胃液中的释放。该实验表明，果胶的存在可以提高纳米分散体的稳定性，并可用于实现生物活性化合物的控制释放。
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