Department of Stomatology, Postgraduate Program in Dentistry; Emphasis on Periodontics, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
Postgraduate Program in Dental Clinic, Federal University of Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Crit Rev Oncol Hematol. 2021 Jun;162:103335. doi: 10.1016/j.critrevonc.2021.103335. Epub 2021 May 13.
Head and neck squamous cell carcinoma is one of the most common neoplasms. Radiotherapy (RT) plays an essential role in the management of such cases. Despite advances in the technique, hyposalivation, xerostomia, dysphagia, trismus, radiation caries, and osteoradionecrosis remain significant late complications of RT. The aim of this narrative review was to summarize and update the main findings related to late side effects of radiotherapy in survivors of head and neck cancer (HNC). Such effects limit the ability to speak, ingest food and medications, and breathe and also exert a negative impact on social well-being and quality of life. This review highlights research in the field for both researchers and clinicians, assisting in the prevention and management of these adverse conditions. The findings can contribute to improving preventive management and multidisciplinary interventions for HNC patients.
头颈部鳞状细胞癌是最常见的肿瘤之一。放射治疗（RT）在这类病例的治疗中起着至关重要的作用。尽管技术有所进步，但唾液减少、口干、吞咽困难、牙关紧闭、放射性龋齿和放射性骨坏死仍然是 RT 的严重晚期并发症。本综述的目的是总结和更新与头颈部癌症（HNC）幸存者放疗后晚期副作用相关的主要发现。这些影响限制了患者说话、摄入食物和药物以及呼吸的能力，也对社会福祉和生活质量产生负面影响。本综述突出了该领域的研究成果，为研究人员和临床医生提供了帮助，有助于预防和管理这些不利情况。这些发现有助于改善 HNC 患者的预防管理和多学科干预。
