Department of Public Health, Yonsei University Graduate School, Seoul, Korea.
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
J Affect Disord. 2021 Jul 1;290:109-116. doi: 10.1016/j.jad.2021.04.062. Epub 2021 May 1.
The present study aimed to investigate the association between resilience and cognitive function of middle-aged Koreans in a longitudinal setting.
We utilized the baseline and 5-year follow-up data from the Cardiovascular and Metabolic Diseases Etiology Research Center study. The final number of participants included in the analysis was 397 (108 men, 289 women, mean age 55.4 years) who had valid measurements of both baseline resilience and Mini-Mental State Estimation at follow-up. The resilient people at baseline were operationally defined as the people who had at least one negative experience in the Life Experience Survey without depression, which was defined as a Beck Depressive Inventory-Ⅱ score of 20 or above. Cognitive function was evaluated by the Korean version of the Mini-Mental State Examination in both surveys. A generalized linear model was applied after adjusting for confounders. The association between resilience and cognitive function was further analyzed using stratification by median age and education level.
At follow-up, only in men, the resilience group showed a higher MMSE level compared to the reference group (β = 1.3, p = 0.002). Stratified by median age, both the younger group (β = 1.2, SE = 0.5, p = 0.031) and the older group among men (β = 2.1, SE = 0.7, p = 0.0069) showed a positive association between resilience and cognitive functions. However, when stratified by education level, only the low-education group presented the association (β = 1.7, SE = 0.5, p = 0.002). In women, no significant results were found.
This study had limited number of participants.
Resilience at baseline was associated with more well-preserved cognitive function at follow-up in men.
本研究旨在探讨中年韩国人在纵向研究中韧性与认知功能之间的关系。
我们利用心血管和代谢疾病病因学研究中心研究的基线和 5 年随访数据。分析中最终纳入的参与者人数为 397 人（108 名男性，289 名女性，平均年龄 55.4 岁），他们在随访时均有基线韧性和简易精神状态评估的有效测量值。基线时的韧性人群被定义为在生活经历调查中至少有一次负面经历但没有抑郁的人群，即贝克抑郁量表Ⅱ得分为 20 或以上。两次调查均使用韩国版简易精神状态检查评估认知功能。调整混杂因素后，应用广义线性模型进行分析。进一步通过年龄中位数和教育水平进行分层，分析韧性与认知功能之间的关系。
随访时，仅在男性中，韧性组的 MMSE 评分高于参照组（β=1.3，p=0.002）。按年龄中位数分层，男性中的年轻组（β=1.2，SE=0.5，p=0.031）和老年组（β=2.1，SE=0.7，p=0.0069）均显示韧性与认知功能之间存在正相关。然而，按教育水平分层时，只有低教育组存在相关性（β=1.7，SE=0.5，p=0.002）。在女性中，未发现显著结果。
本研究的参与者人数有限。
基线时的韧性与男性随访时更好的认知功能相关。
