Caruso Vanni, Zuccarini Mariachiara, Di Iorio Patrizia, Muhammad Ishaq, Ronci Maurizio
School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS, Australia.
Institute for Research on Pain, ISAL-Foundation, Rimini, Italy.
Front Pharmacol. 2021 Apr 29;12:655989. doi: 10.3389/fphar.2021.655989. eCollection 2021.
The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.
嘌呤能信号在能量稳态调节中具有既定作用，但越来越多的证据表明其在食物摄入控制中也有涉及。在本综述中，我们对嘌呤能受体激活后下丘脑神经元内导致摄食行为改变的分子机制进行了综合阐述。我们还强调了嘌呤能信号在代谢稳态中的重要性以及靶向其受体用于治疗目的的可能性。
