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抗菌药物管理与抗菌谱:超越传统抗菌谱的重要性

Antimicrobial stewardship and antibiograms: importance of moving beyond traditional antibiograms.

作者信息

Klinker Kenneth P, Hidayat Levita K, DeRyke C Andrew, DePestel Daryl D, Motyl Mary, Bauer Karri A

机构信息

MRL, Merck & Co., Inc., Kenilworth, NJ, USA.

MRL, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.

出版信息

Ther Adv Infect Dis. 2021 May 5;8:20499361211011373. doi: 10.1177/20499361211011373. eCollection 2021 Jan-Dec.

Abstract

The rapid evolution of resistance, particularly among Gram-negative bacteria, requires appropriate identification of patients at risk followed by administration of appropriate empiric antibiotic therapy. A primary tenet of antimicrobial stewardship programs (ASPs) is the establishment of empiric antibiotic recommendations for commonly encountered infections. An important tool in providing empiric antibiotic therapy recommendations is the use of an antibiogram. While the majority of institutions use a traditional antibiogram, ASPs have an opportunity to enhance antibiogram data. The authors provide the rationale for why ASPs should implement alternative antibiograms, and the importance of incorporating an antibiogram into clinical decision support systems with the goal of providing effective empiric antibiotic therapy.

摘要

耐药性的迅速演变,尤其是在革兰氏阴性菌中,需要对有风险的患者进行适当识别,随后给予适当的经验性抗生素治疗。抗菌药物管理计划(ASP)的一个主要原则是针对常见感染制定经验性抗生素推荐。提供经验性抗生素治疗推荐的一个重要工具是使用抗菌谱。虽然大多数机构使用传统的抗菌谱,但ASP有机会增强抗菌谱数据。作者阐述了ASP应实施替代抗菌谱的理由,以及将抗菌谱纳入临床决策支持系统以提供有效的经验性抗生素治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c1/8111534/f5f8be20aae7/10.1177_20499361211011373-fig1.jpg

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