Crisci Timothy, Arregui Samuel, Canas Jorge, Hooks Jenaya, Chan Melvin, Powers Cory, Schwaderer Andrew L, Hains David S, Starr Michelle C
Medicine-Pediatric Residency, Indiana University, Indianapolis, IN, United States.
Division of Nephrology, Department of Pediatrics, Indiana University, Indianapolis, IN, United States.
Front Pediatr. 2021 Apr 29;9:633082. doi: 10.3389/fped.2021.633082. eCollection 2021.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease COVID-19 (coronavirus disease 2019) has presented graduate medical education (GME) training programs with a unique set of challenges. One of the most pressing is how should hospital systems that rely on graduate medical residents provide appropriate care for patients while protecting trainees. This question is of particular concern as healthcare workers are at high risk of SARS-CoV-2 exposure. This cross-sectional study sought to assess the impact of hospital COVID-19 patient placement on pediatric graduate medical residents by comparing rates of SARS-CoV-2 seroconversion rates of residents who worked on designated COVID-19 teams and those who did not. Forty-four pediatric and medicine-pediatric residents at Riley Children's Hospital (Indianapolis, IN) were tested for SARS-CoV-2 immunoglobulin M (IgM) and IgG seroconversion in May 2020 using enzyme-linked immunosorbent assays (Abnova catalog no. KA5826), 2 months after the first known COVID-19 case in Indiana. These residents were divided into two groups: those residents who worked on designated COVID-19 teams, and those who did not. Groups were compared using χ or Fisher exact test for categorical variables, and continuous variables were compared using Student testing. Forty-four of 104 eligible residents participated in this study. Despite high rates of seroconversion, there was no difference in the risk of SARS-CoV-2 seroconversion between residents who worked on designated COVID-19 teams (26% or 8/31) and those who did not (31% or 4/13). Eleven of 44 residents (25%) tested positive for SARS-CoV-2 IgG, whereas only 5/44 (11.4%) tested positive for SARS-CoV-2 IgM, without a detectable difference between exposure groups. We did not observe a difference in SARS-CoV-2 seroconversion between different exposure groups. These data are consistent with growing evidence supporting the efficacy of personal protective equipment. Further population-based research on the role of children in transmitting the SARS-CoV-2 virus is needed to allow for a more evidence-based approach toward managing the COVID-19 pandemic.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）及其相关疾病COVID-19（2019冠状病毒病）给毕业后医学教育（GME）培训项目带来了一系列独特的挑战。最紧迫的问题之一是，依赖住院医师的医院系统应如何在保护受训人员的同时为患者提供适当的护理。随着医护人员面临SARS-CoV-2暴露的高风险，这个问题尤为令人担忧。这项横断面研究旨在通过比较在指定的COVID-19团队工作的住院医师和未在该团队工作的住院医师的SARS-CoV-2血清转化率，评估医院COVID-19患者安置对儿科毕业后医学住院医师的影响。2020年5月，印第安纳波利斯莱利儿童医院的44名儿科和儿内科住院医师接受了SARS-CoV-2免疫球蛋白M（IgM）和IgG血清转化检测，采用酶联免疫吸附测定法（Abnova产品编号KA5826），此时距离印第安纳州首例已知COVID-19病例已有2个月。这些住院医师被分为两组：在指定的COVID-19团队工作的住院医师和未在该团队工作的住院医师。分类变量采用χ²检验或Fisher精确检验进行组间比较，连续变量采用Student检验进行比较。104名符合条件的住院医师中有44名参与了本研究。尽管血清转化率很高，但在指定的COVID-19团队工作的住院医师（26%或8/31）和未在该团队工作的住院医师（
