Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Red Bank Veterinary Hospital, Tinton Falls, New Jersey, USA.
J Vet Intern Med. 2021 Jul;35(4):1943-1949. doi: 10.1111/jvim.16162. Epub 2021 May 17.
Laryngeal paralysis commonly affects older Labrador retrievers. Currently, dogs with severe disease require surgical intervention, most commonly arytenoid lateralization. Anecdotally, doxepin has been proposed to help dogs with laryngeal paralysis.
Doxepin will improve quality of life measures assessed by owners of Labrador retrievers with laryngeal paralysis not requiring emergency surgery.
Twenty-two Labrador retrievers with laryngeal paralysis.
Dogs were randomized to receive doxepin (3-5 mg/kg q12h PO) or placebo for 28 days. Owners completed quality-of-life assessments before and after completing the study. Data were compared between groups using Rank-Sum tests or Fisher's exact tests.
The 2 groups of dogs did not differ at baseline except for owner-perceived degree of ataxia (owners of dogs receiving doxepin considered them more ataxic than owners of dogs receiving placebo). After 28 days, owner-assessed quality of life measures did not differ between dogs receiving doxepin or placebo (dogs worsening: doxepin = 2, placebo = 1; dogs unchanged: doxepin = 6, placebo = 7; dogs improved: doxepin = 4, placebo = 2; P = .84). Dogs receiving placebo had a greater improvement in client-assessed overall health than dogs receiving doxepin (mean ranks: doxepin = 4.36, placebo = 6.64; P = .04). The study was terminated at this interim analysis.
Doxepin did not appear to improve any measures of owner-assessed quality of life in Labrador retrievers with laryngeal paralysis.
喉麻痹常影响老年拉布拉多猎犬。目前，病情严重的犬需要手术干预，最常见的是杓状软骨侧移术。据报道，地昔帕明可用于帮助患有喉麻痹的犬。
地昔帕明将改善不需要紧急手术的喉麻痹拉布拉多犬主人评估的生活质量指标。
22 只患有喉麻痹的拉布拉多犬。
犬被随机分为地昔帕明（3-5mg/kg q12h PO）或安慰剂组，疗程 28 天。主人在完成研究前后完成生活质量评估。使用秩和检验或 Fisher 确切检验比较组间数据。
除了主人感知的共济失调程度（接受地昔帕明的犬的主人认为它们比接受安慰剂的犬更共济失调）外，两组犬在基线时没有差异。28 天后，接受地昔帕明或安慰剂的犬的主人评估的生活质量指标没有差异（恶化：地昔帕明=2，安慰剂=1；不变：地昔帕明=6，安慰剂=7；改善：地昔帕明=4，安慰剂=2；P=0.84）。接受安慰剂的犬的客户评估的整体健康状况比接受地昔帕明的犬改善更大（平均秩：地昔帕明=4.36，安慰剂=6.64；P=0.04）。在这项中期分析中，研究终止。
地昔帕明似乎没有改善喉麻痹拉布拉多犬主人评估的任何生活质量指标。
