盐酸利托君致低剂量急性肺水肿：1 例报告。
Acute Pulmonary Edema Induced by a Low Dose of Ritodrine Hydrochloride: A Case Report.
机构信息
Department of Obstetrics and Gynecology, Palmore Hospital, Hyogo, Japan.
Department of Anesthesiology, Palmore Hospital, Hyogo, Japan.
出版信息
Kobe J Med Sci. 2021 Mar 25;66(5):E166-E169.
OBJECTIVE
Acute pulmonary edema associated with ritodrine hydrochloride is a rare, life-threatening complication, and dose and duration of ritodrine use are closely associated with this pathology. We report a case of acute pulmonary edema associated with short-duration infusion of ritodrine hydrochloride in a patient with pectus excavatum as an underlying factor.
CASE REPORT
A 30-year-old healthy pregnant woman was treated with oral ritodrine for tocolysis between 31 and 35 weeks of pregnancy. At 36 weeks of gestation, she went into preterm labor, with premature rupture of the membrane and breech presentation, and received an infusion of ritodrine hydrochloride for a few hours. Although she was normotensive until labor onset, mild hypertension and proteinuria were recognized. Intraoperatively, a funnel-chest deformity was observed, and she developed postoperative pulmonary edema associated with dyspnea and wet cough and confirmed on chest radiography and arterial gas analysis, and recovered with supportive care.
CONCLUSION
Small-dose infusion of ritodrine hydrochloride might cause pulmonary edema in patients with underlying medical problems, including pectus excavatum.
目的
盐酸利托君相关性急性肺水肿是一种罕见的、危及生命的并发症，利托君的剂量和使用时间与这种病理密切相关。我们报告了一例漏斗胸患者在使用盐酸利托君短时间输注后发生急性肺水肿的病例。
病例报告
一名 30 岁健康孕妇在妊娠 31 至 35 周期间接受口服利托君进行保胎治疗。在 36 周妊娠时，她出现早产、胎膜早破和臀位，接受了数小时的盐酸利托君输注。尽管她在分娩前血压正常，但出现了轻度高血压和蛋白尿。术中观察到漏斗胸畸形，她出现了与呼吸困难和湿咳相关的术后肺水肿，并通过胸部 X 线和动脉血气分析得到证实，通过支持性治疗后恢复。
结论
小剂量输注盐酸利托君可能会导致患有漏斗胸等基础疾病的患者发生肺水肿。
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