Department of Neurobiology and Animal Physiology, Behavioural and Molecular Neurobiology, University of Regensburg, Universitaetstraße, Regensburg, Bavaria, Germany.
Department of Neurobiology and Animal Physiology, Neurophysiology, University of Regensburg, Regensburg, Germany.
Nat Commun. 2021 May 18;12(1):2900. doi: 10.1038/s41467-021-23064-5.
In contrast to male rats, aggression in virgin female rats has been rarely studied. Here, we established a rat model of enhanced aggression in females using a combination of social isolation and aggression-training to specifically investigate the involvement of the oxytocin (OXT) and arginine vasopressin (AVP) systems within the lateral septum (LS). Using neuropharmacological, optogenetic, chemogenetic as well as microdialysis approaches, we revealed that enhanced OXT release within the ventral LS (vLS), combined with reduced AVP release within the dorsal LS (dLS), is required for aggression in female rats. Accordingly, increased activity of putative OXT receptor-positive neurons in the vLS, and decreased activity of putative AVP receptor-positive neurons in the dLS, are likely to underly aggression in female rats. Finally, in vitro activation of OXT receptors in the vLS increased tonic GABAergic inhibition of dLS neurons. Overall, our data suggest a model showing that septal release of OXT and AVP differentially affects aggression in females by modulating the inhibitory tone within LS sub-networks.
与雄性大鼠相比，发情期雌性大鼠的攻击性很少被研究。在这里，我们使用社交隔离和攻击性训练相结合的方法建立了一种雌性大鼠攻击性增强的大鼠模型，专门研究了外侧隔核（LS）内催产素（OXT）和精氨酸加压素（AVP）系统的参与。通过神经药理学、光遗传学、化学遗传学以及微透析方法，我们揭示了 LS 腹侧部（vLS）内增强的 OXT 释放，与 LS 背侧部（dLS）内 AVP 释放减少相结合，是雌性大鼠攻击性所必需的。因此，vLS 中推定的 OXT 受体阳性神经元的活性增加，以及 dLS 中推定的 AVP 受体阳性神经元的活性降低，可能是雌性大鼠攻击性的基础。最后，在 LS 腹侧部体外激活 OXT 受体增加了 LS 亚网络内 dLS 神经元的紧张性 GABA 抑制。总的来说，我们的数据表明，隔核中 OXT 和 AVP 的释放通过调节 LS 亚网络内的抑制性张力，以不同的方式影响雌性大鼠的攻击性。
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