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Recall reaction of a severe local peripheral neuropathy after paclitaxel extravasation.
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Fluocinolone Acetonide Enhances Anterograde Mitochondria Trafficking and Promotes Neuroprotection against Paclitaxel-Induced Peripheral Neuropathy.
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本文引用的文献

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Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7.
Brain. 2021 Jul 28;144(6):1727-1737. doi: 10.1093/brain/awab113.
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Long-lasting analgesia via targeted in situ repression of Na1.7 in mice.
Sci Transl Med. 2021 Mar 10;13(584). doi: 10.1126/scitranslmed.aay9056.
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The Role of Voltage-Gated Sodium Channels in Pain Signaling.
Physiol Rev. 2019 Apr 1;99(2):1079-1151. doi: 10.1152/physrev.00052.2017.
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DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain.
J Neurosci. 2018 Jan 31;38(5):1124-1136. doi: 10.1523/JNEUROSCI.0899-17.2017. Epub 2017 Dec 18.
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Paclitaxel Reduces Axonal Bclw to Initiate IPR1-Dependent Axon Degeneration.
Neuron. 2017 Oct 11;96(2):373-386.e6. doi: 10.1016/j.neuron.2017.09.034.
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Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.
J Peripher Nerv Syst. 2017 Sep;22(3):162-171. doi: 10.1111/jns.12219.
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Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects.
Exp Neurol. 2017 Feb;288:153-166. doi: 10.1016/j.expneurol.2016.11.015. Epub 2016 Nov 26.
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The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions.
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The Na(V)1.7 sodium channel: from molecule to man.
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