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中国汉族人群中基因多态性与颅内动脉瘤易感性增加的关联

Association of / Gene Polymorphisms with Increased Susceptibility to Intracranial Aneurysm in a Chinese Han Population.

作者信息

Cui Xiaopeng, Xin Wen-Qiang, Wang Bangyue, Zhao Yan, Hou Changkai, Cai Shifei, Peng Chao, Wang Zhen, Li Jian, Huan Linchun, Chen Lei, Yang Xinyu

机构信息

Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Department of Neurosurgery, Tianjin Fifth Central Hospital, Tianjin, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2021 May 12;17:1443-1449. doi: 10.2147/NDT.S306542. eCollection 2021.

DOI:10.2147/NDT.S306542
PMID:34012264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8126964/
Abstract

OBJECTIVE

Several studies have reported that single-nucleotide polymorphisms (SNPs) of the / gene on chromosome 9p21.3 are associated with increased risk of intracranial aneurysm (IA). However, the association between IAs and SNPs of / in Chinese Han people is yet to be evaluated. This study examined the association of the SNPs rs10811661 and rs4977574 with IA in the Chinese Han population.

METHODS

A total of 595 IA patients and 600 sex- and age-matched controls were enrolled in the study. Peripheral blood was collected and stored at -80°C until use. / was identified using polymerase chain reaction-ligase detection reaction. SNP genotyping was performed for rs10811661 and rs4977574 using a MassArray system. Associations between these two SNPs and IAs was tested with χ or Fisher's exact tests and multivariate logistic regression.

RESULTS

rs10811661 and rs4977574 were significantly associated with IA. The frequency of rs10811661-T in IA was higher than in controls (OR 1.26, 95% CI 1.07-1.49; <0.01). There was no significant difference in frequency of haplotype between control subjects and IA patients.

CONCLUSION

rs10811661 and rs4977574 on 9p21.3 were strongly associated with genetic susceptibility to IA in the Chinese Han population, which emphasizes a need for further investigation.

摘要

目的

多项研究报告称，9号染色体p21.3区域/基因的单核苷酸多态性（SNP）与颅内动脉瘤（IA）风险增加相关。然而，汉族人群中IA与/基因SNP之间的关联尚未得到评估。本研究检测了SNP rs10811661和rs4977574与汉族人群IA的关联。

方法

本研究共纳入595例IA患者和600例性别及年龄匹配的对照。采集外周血并储存在-80°C直至使用。通过聚合酶链反应-连接酶检测反应鉴定/。使用MassArray系统对rs10811661和rs4977574进行SNP基因分型。使用χ²检验或Fisher精确检验以及多因素逻辑回归分析这两个SNP与IA之间的关联。

结果

rs10811661和rs4977574与IA显著相关。IA患者中rs10811661-T的频率高于对照组（比值比1.26，95%置信区间1.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a2/8126964/0bb5de4b2a5c/NDT-17-1443-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a2/8126964/0bb5de4b2a5c/NDT-17-1443-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a2/8126964/0bb5de4b2a5c/NDT-17-1443-g0001.jpg

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本文引用的文献

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BMC Neurol. 2017 Dec 11;17(1):214. doi: 10.1186/s12883-017-0986-z.
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Genet Mol Res. 2015 Jun 18;14(2):6865-78. doi: 10.4238/2015.June.18.30.
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一种功能性长链非编码RNA HOTAIR基因变异与胃癌易感性有关。
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