芥子油可兴奋但不抑制大鼠背角伤害性神经元：推测对A-δ纤维有作用。
Mustard oil excites but does not inhibit nociceptive dorsal horn neurones in the rat: a presumed effect on A-delta fibres.
作者信息
Harris N C, Ryall R W
机构信息
Department of Pharmacology, University of Cambridge.
出版信息
Br J Pharmacol. 1988 May;94(1):180-4. doi: 10.1111/j.1476-5381.1988.tb11513.x.
Abstract
- Mustard oil was applied topically in concentrations of 10-20% to the excitatory and inhibitory nociceptive receptive fields in glabrous and hairy skin of the anesthetized rat while recording the activity of nociceptive dorsal horn neurones. The noxious stimulus was radiant heat which is known to activate C-fibres in glabrous and hairy skin. 2. Mustard oil had little effect when applied to glabrous skin and this was attributed to poor penetration of the skin. 3. Mustard oil excited cells in the dorsal horn which were excited by noxious heat in the receptive field on hairy skin. 4. Mustard oil excited cells in the dorsal horn which were inhibited by noxious heat in the receptive field on hairy skin. 5. Inhibitory effects of mustard oil were never seen, even when applied to receptive fields in which noxious heating caused inhibition. 6. The excitatory effects of mustard oil on cells inhibited by noxious heating of the skin are attributed to the reported activation of A-delta fibres which probably masked any C-fibre activation.
摘要
- 在记录麻醉大鼠伤害性背角神经元活动时，将浓度为10% - 20%的芥子油局部涂抹于无毛和有毛皮肤的兴奋性和抑制性伤害性感受野。有害刺激为辐射热，已知其可激活无毛和有毛皮肤中的C纤维。2. 芥子油涂抹于无毛皮肤时作用甚微，这归因于其对皮肤的渗透性较差。3. 芥子油兴奋了背角中那些在有毛皮肤感受野中被有害热刺激所兴奋的细胞。4. 芥子油兴奋了背角中那些在有毛皮肤感受野中被有害热刺激所抑制的细胞。5. 即使将芥子油涂抹于有害热刺激可引起抑制的感受野，也从未观察到其抑制作用。6. 芥子油对被皮肤有害热刺激所抑制的细胞的兴奋作用归因于据报道的A - δ纤维的激活，这可能掩盖了任何C纤维的激活。
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