中和 Ljungan 病毒抗体在新诊断的 1 型糖尿病患儿中的作用。
Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes.
机构信息
Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital, Malmö, Sweden.
IHRC, Inc, under contract to Polio and Picornavirus Laboratory Branch, Centers for Disease Control and Prevention, Division of Viral Diseases, Atlanta GA, USA.
出版信息
J Gen Virol. 2021 May;102(5). doi: 10.1099/jgv.0.001602.
(LV), a of the family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (=67) and school children controls (=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (=0.023), but not to autoantibodies against insulin (IAA) or islet antigen-2 (IA-2A). The NLVA assay should prove useful for further investigations to determine levels of LV antibodies in patients and future studies to determine a possible role of LV in autoimmune type 1 diabetes.
（LV），柯萨奇病毒 B3 属的一种病毒，最初从瑞典吕根河的一种田鼠中分离出来，与自身免疫性 1 型糖尿病的发病风险相关。使用原始的 87-012 LV 分离株，开发了一种用于检测 Ljungan 病毒中和抗体（NLVA）的方法。该方法的目的是确定瑞典耶姆特兰县新诊断为 1 型糖尿病的 0-18 岁患者（=67）和在校儿童对照组（=292）中的 NLVA 滴度。结果发现，67 名患者中有 41 名（61%）存在 NLVA，而 292 名对照组中有 127 名（44%）（=0.009）。在 1 型糖尿病患者中，NLVA 滴度与谷氨酸脱羧酶自身抗体（GADA）相关（=0.023），但与胰岛素自身抗体（IAA）或胰岛抗原-2 自身抗体（IA-2A）无关。该 NLVA 检测方法有望用于进一步研究，以确定患者中 LV 抗体的水平，并在未来的研究中确定 LV 在自身免疫性 1 型糖尿病中的可能作用。
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