体感第二皮层诱发电位反应与极早产儿 6 年神经发育结局。
Secondary somatosensory cortex evoked responses and 6-year neurodevelopmental outcome in extremely preterm children.
机构信息
Child Neurology, New Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; BioMag Laboratory, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
BioMag Laboratory, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
出版信息
Clin Neurophysiol. 2021 Jul;132(7):1572-1583. doi: 10.1016/j.clinph.2021.04.005. Epub 2021 Apr 28.
OBJECTIVE
We assessed in extremely preterm born (EPB) children whether secondary somatosensory cortex (SII) responses recorded with magnetoencephalography (MEG) at term-equivalent age (TEA) correlate with neurodevelopmental outcome at age 6 years. Secondly, we assessed whether SII responses differ between 6-year-old EPB and term-born (TB) children.
METHODS
39 EPB children underwent MEG with tactile stimulation at TEA. At age 6 years, 32 EPB and 26 TB children underwent MEG including a sensorimotor task requiring attention and motor inhibition. SII responses to tactile stimulation were modeled with equivalent current dipoles. Neurological outcome, motor competence, and general cognitive ability were prospectively evaluated at age 6 years.
RESULTS
Unilaterally absent SII response at TEA was associated with abnormal motor competence in 6-year-old EPB children (p = 0.03). At age 6 years, SII responses were bilaterally detectable in most EPB (88%) and TB (92%) children (group comparison, p = 0.69). Motor inhibition was associated with decreased SII peak latencies in TB children, but EPB children lacked this effect (p = 0.02).
CONCLUSIONS
Unilateral absence of an SII response at TEA predicted poorer motor outcome in EPB children.
SIGNIFICANCE
Neurophysiological methods may provide new means for outcome prognostication in EPB children.
目的
我们评估了极早产儿（EPB）在胎龄相当（TEA）时的体感第二皮层（SII）的脑磁图（MEG）反应是否与 6 岁时的神经发育结果相关。其次，我们评估了 SII 反应在 6 岁时的 EPB 和足月（TB）儿童之间是否存在差异。
方法
39 名 EPB 儿童在 TEA 时接受了体感刺激的 MEG。在 6 岁时，32 名 EPB 和 26 名 TB 儿童接受了 MEG，其中包括需要注意力和运动抑制的感觉运动任务。使用等效电流偶极子对触觉刺激的 SII 反应进行建模。在 6 岁时，前瞻性地评估了神经发育结果、运动能力和一般认知能力。
结果
TEA 时单侧缺失 SII 反应与 6 岁 EPB 儿童的运动能力异常相关（p=0.03）。在 6 岁时，SII 反应在大多数 EPB（88%）和 TB（92%）儿童中双侧可检测到（组间比较，p=0.69）。运动抑制与 TB 儿童的 SII 峰潜伏期降低有关，但 EPB 儿童缺乏这种效应（p=0.02）。
结论
TEA 时 SII 反应的单侧缺失预测了 EPB 儿童的运动结局较差。
意义
神经生理学方法可能为 EPB 儿童的预后提供新的手段。
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