Jovanovic Ana Munjiza, Mitkovic-Voncina Marija, Kostic Milutin, Jeremic Marija, Todorovic Jovana, Popadic Dusan, Tosevski Dusica Lecic, Markovic Ivanka
Institute of Mental Health, Belgrade, Serbia; Department of Psychiatry, School of Medicine, University of Belgrade, Belgrade, Serbia.
Institute of Mental Health, Belgrade, Serbia; Department of Psychiatry, School of Medicine, University of Belgrade, Belgrade, Serbia.
Psychiatry Res. 2021 Jul;301:113987. doi: 10.1016/j.psychres.2021.113987. Epub 2021 May 9.
Transforming growth factor beta (TGF-β), which has a role as a regulatory cytokine, has not been widely investigated in patients with major depressive disorder (MDD) who experienced childhood trauma. The aim of our study was to investigate the differences in circulating TGF-β levels between the patients with major depressive disorder (MDD) with and without child maltreatment (CM) history, and to compare them to the corresponding control subjects' groups (with or without CM). Blood samples were obtained from 55 patients, fulfilling DSM-IV-R criteria for a current MDD episode without psychotic symptoms, and 45 healthy controls, matched for age and gender. Participants were administered the Childhood Trauma Questionnaire (CTQ). Serum TGF-β concentration was determined by enzyme-linked immunosorbent assay. The concentration of TGF-β was significantly higher in patients with MDD with CM history, compared to MDD patients with no CM, as well as both control groups. Furthermore, we have shown that the combined effect of CM history and MDD affected TGF-β levels in adulthood, which was not observed in the control group with CM. These results indicate that MDD patients with the experience of CM have altered immune-regulatory response, and they may constitute a specific subtype within this heterogenic disorder (ecophenotype).
转化生长因子β（TGF-β）作为一种调节性细胞因子，在经历过童年创伤的重度抑郁症（MDD）患者中尚未得到广泛研究。我们研究的目的是调查有和没有儿童期虐待（CM）史的重度抑郁症（MDD）患者循环TGF-β水平的差异，并将其与相应的对照组（有或没有CM）进行比较。从55名符合DSM-IV-R标准的当前无精神病症状的MDD发作患者和45名年龄和性别匹配的健康对照者中采集血样。参与者接受儿童创伤问卷（CTQ）评估。通过酶联免疫吸附测定法测定血清TGF-β浓度。与没有CM的MDD患者以及两个对照组相比，有CM史的MDD患者中TGF-β浓度显著更高。此外，我们已经表明，CM史和MDD的联合作用影响成年期的TGF-β水平，而在有CM的对照组中未观察到这种情况。这些结果表明，有CM经历的MDD患者具有改变的免疫调节反应，并且他们可能构成这种异质性疾病（生态表型）中的一个特定亚型。
