新生儿和婴儿中的丙型肝炎病毒

Hepatitis C Virus in Neonates and Infants.

作者信息

Epstein Rachel L, Espinosa Claudia

机构信息

Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, 801 Massachusetts Avenue, Crosstown Center 2nd Floor, Boston, MA 02118, USA.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA.

出版信息

Clin Perinatol. 2021 Jun;48(2):343-357. doi: 10.1016/j.clp.2021.03.007.

DOI:10.1016/j.clp.2021.03.007

PMID:34030818

Abstract

Hepatitis C virus prevalence has steeply risen among pregnant women in association with the opioid epidemic and the major national infectious diseases and liver society guidelines recommend universal hepatitis C virus testing in pregnancy. All infants born to mothers with hepatitis C virus infection should be evaluated. Many children spontaneously clear hepatitis C virus or remain minimally symptomatic, but some develop significant liver disease if untreated. With hepatitis C virus cure available starting at age 3, we must improve programs to identify and cure hepatitis C virus-infected women and infants with the goal of eliminating mother-to-child transmission.

摘要

丙型肝炎病毒在孕妇中的流行率随着阿片类药物流行而急剧上升，主要的国家传染病和肝脏学会指南建议对孕妇进行丙型肝炎病毒普遍检测。所有丙型肝炎病毒感染母亲所生的婴儿都应接受评估。许多儿童会自发清除丙型肝炎病毒或仅有轻微症状，但有些儿童如果不接受治疗会发展为严重肝病。鉴于3岁起即可治愈丙型肝炎病毒，我们必须改进项目，以识别和治愈丙型肝炎病毒感染的妇女和婴儿，目标是消除母婴传播。