先天性腹壁发育不全的预后：单纯型与复杂型先天性腹壁发育不全的围生期预期。

Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis.

机构信息

Department of Surgery, Children's Mercy Kansas City, Kansas City, MO, USA.

Center for Surgical Outcomes Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.

出版信息

J Perinatol. 2021 Jul;41(7):1755-1759. doi: 10.1038/s41372-021-01093-8. Epub 2021 May 25.

DOI:10.1038/s41372-021-01093-8

PMID:34035447

Abstract

OBJECTIVE

To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling.

STUDY DESIGN

A retrospective study of 394 neonates with gastroschisis at 11 children's hospitals from January 2013 to March 2017 was performed. Analysis by Fisher's exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported.

RESULT

There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%).

CONCLUSION

This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.

摘要

目的

为了在咨询过程中为大量多机构队列中的简单先天性脐膨出（SG）和复杂先天性脐膨出（CG）患者提供可推广的预期结果估计。

研究设计

对 2013 年 1 月至 2017 年 3 月期间 11 家儿童医院的 394 例先天性脐膨出新生儿进行了回顾性研究。采用 Fisher 精确检验和 Wilcoxon 秩和检验进行分析。报告了复杂和简单先天性脐膨出的结果。

结果

有 315 例（80%）为 SG，79 例（20%）为 CG。CG 从出生到关闭的时间（6 天 vs. 4.4 天）、关闭到目标喂养的时间（69 天 vs. 23 天）、呼吸机使用（90% vs. 73%）、SSI（31% vs. 11%）、NEC（14% vs. 6%）、PN 使用（71 天 vs. 24 天）、住院时间（104.5 天 vs. 33 天）和死亡率（11% vs. 0%）均增加。