Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Moscow Oblast, Russia.
Molecular Evolution Laboratory, Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevitch Institute), Moscow, Russia.
Genome Biol Evol. 2021 Jul 6;13(7). doi: 10.1093/gbe/evab113.
In a wide range of taxa, proteins encoded by mitochondrial genomes are involved in adaptation to lifestyle that requires oxygen starvation or elevation of metabolism rate. It remains poorly understood to what extent adaptation to similar conditions is associated with parallel changes in these proteins. We search for a genetic signal of parallel or convergent evolution in recurrent molecular adaptation to high altitude, migration, diving, wintering, unusual flight abilities, or loss of flight in mitochondrial genomes of birds. Developing on previous work, we design an approach for the detection of recurrent coincident changes in genotype and phenotype, indicative of an association between the two. We describe a number of candidate sites involved in recurrent adaptation in ND genes. However, we find that the majority of convergence events can be explained by random coincidences without invoking adaptation.
在广泛的分类群中，由线粒体基因组编码的蛋白质参与了对需要缺氧或代谢率升高的生活方式的适应。对于适应类似条件与这些蛋白质的平行变化之间的关联程度，我们知之甚少。我们在鸟类线粒体基因组中反复出现的对高海拔、迁徙、潜水、越冬、异常飞行能力或丧失飞行的分子适应中寻找平行或趋同进化的遗传信号。在前人的工作基础上，我们设计了一种检测基因型和表型反复出现的吻合变化的方法，这表明两者之间存在关联。我们描述了一些与 ND 基因中反复适应有关的候选位点。然而，我们发现大多数趋同事件可以用没有涉及适应的随机巧合来解释。
