School of Materials Science and Chemical Engineering, Ningbo University of Technology, 201 Fenghua Road, Jiangbei, Ningbo 315211, China.
Molecules. 2021 May 4;26(9):2688. doi: 10.3390/molecules26092688.
Hydrogel adhesives are attractive for applications in intelligent soft materials and tissue engineering, but conventional hydrogels usually have poor adhesion. In this study, we designed a strategy to synthesize a novel adhesive with a thin hydrogel adhesive layer integrated on a tough substrate hydrogel. The adhesive layer with positive charges of ammonium groups on the polymer backbones strongly bonds to a wide range of nonporous materials' surfaces. The substrate layer with a dual hydrogen bond system consists of (i) weak hydrogen bonds between ,-dimethyl acrylamide (DMAA) and acrylic acid (AAc) units and (ii) strong multiple hydrogen bonds between 2-ureido-4[1H]-pyrimidinone (UPy) units. The dual hydrogen-bond network endowed the hydrogel adhesives with unique mechanical properties, e.g., toughness, highly stretchability, and insensitivity to notches. The hydrogel adhesion to four types of materials like glass, 316L stainless steel, aluminum, AlO ceramic, and two biological tissues including pig skin and pig kidney was investigated. The hydrogel bonds strongly to dry solid surfaces and wet tissue, which is promising for biomedical applications.
水凝胶粘合剂在智能软材料和组织工程中有很大的吸引力，但传统的水凝胶通常附着力差。在这项研究中，我们设计了一种策略，合成了一种具有薄水凝胶粘合层集成在坚韧的基底水凝胶上的新型粘合剂。聚合物主链上带正电荷的铵基团的粘合层与广泛的无孔材料表面强烈结合。具有双氢键体系的基底层由（i）-二甲基丙烯酰胺（DMAA）和丙烯酸（AAc）单元之间的弱氢键和（ii）2-尿嘧啶-4[1H]-嘧啶酮（UPy）单元之间的强多重氢键组成。双氢键网络赋予水凝胶粘合剂独特的机械性能，例如韧性、高拉伸性和对切口不敏感。研究了水凝胶对玻璃、316L 不锈钢、铝、AlO 陶瓷等四种材料以及猪皮和猪肾等两种生物组织的粘附性能。水凝胶与干燥的固体表面和湿润的组织紧密结合，有望应用于生物医学领域。
