Kramer Stanko, Cameron Neil R, Krajnc Peter
PolyOrgLab, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia.
Department of Materials Science and Engineering, Monash University, 22 Alliance Lane, Clayton, VIC 3800, Australia.
Polymers (Basel). 2021 May 28;13(11):1786. doi: 10.3390/polym13111786.
High internal phase emulsions (HIPEs), with densely packed droplets of internal phase and monomers dispersed in the continuous phase, are now an established medium for porous polymer preparation (polyHIPEs). The ability to influence the pore size and interconnectivity, together with the process scalability and a wide spectrum of possible chemistries are important advantages of polyHIPEs. In this review, the focus on the biomedical applications of polyHIPEs is emphasised, in particular the applications of polyHIPEs as scaffolds/supports for biological cell growth, proliferation and tissue (re)generation. An overview of the polyHIPE preparation methodology is given and possibilities of morphology tuning are outlined. In the continuation, polyHIPEs with different chemistries and their interaction with biological systems are described. A further focus is given to combined techniques and advanced applications.
高内相乳液（HIPEs），其内部相的液滴紧密堆积且单体分散在连续相中，现已成为制备多孔聚合物（聚HIPEs）的既定介质。影响孔径和互连性的能力，以及工艺可扩展性和广泛的可能化学性质，是聚HIPEs的重要优势。在本综述中，重点强调了聚HIPEs在生物医学领域的应用，特别是聚HIPEs作为生物细胞生长、增殖和组织（再）生成的支架/支撑物的应用。给出了聚HIPE制备方法的概述，并概述了形态调节的可能性。接着，描述了具有不同化学性质的聚HIPEs及其与生物系统的相互作用。进一步关注了组合技术和先进应用。
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