Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Eur J Clin Invest. 2021 Dec;51(12):e13620. doi: 10.1111/eci.13620. Epub 2021 Jun 2.
68-gallium (Ga-68) ethylenediaminetetraacetic acid (EDTA) aerosols and Galligas were compared in evaluation of inhaled-particle deposition and clearance in volunteers with or without obstructive pulmonary diseases.
Nonsmoking healthy volunteers, healthy smokers, asthma patients and patients with chronic obstructive pulmonary disease (COPD) were recruited to undergo the dynamic lung ventilation positron emission tomography/computerized tomography (PET/CT) scans within two consecutive days. The inhaled particles were Ga-68-labelled carbon nanoparticles (Galligas, 30-60 nm in size) and Ga-68-labelled EDTA aerosols (1-2 μm in size), respectively. The volunteers' lung function parameters were measured for comparison.
Central deposition and inhomogeneity of both tracers were negatively correlated with lung function parameters, including the ratio of forced expiratory volume at 1 second to forced vital capacity (FEV /FVC). The central or hilum deposition of Galligas, but not 68-gallium (Ga-68) EDTA, was negatively correlated with the maximal expiratory flow at 25%, 50% and 75% of the forced vital capacity. Compared with Galligas, Ga-68 EDTA aerosols were more concentrated in the central region in all groups except for the healthy nonsmokers. Ventilation inhomogeneity was more evident when using Ga-68 EDTA aerosols, especially in patients with COPD and asthma patients. In the healthy smokers, the central region accumulated more Ga-68 EDTA at 30 minutes after inhalation than immediately after inhalation. Ga-68 EDTA cleared faster in lungs than Galligas.
Both Galligas and Ga-68 EDTA aerosols can be used for PET/CT lung ventilation scan. However, Ga-68 EDTA aerosols showed more advantages in diagnosis and evaluation of obstructive airway diseases by revealing the inhaled-particle deposition and clearance.
比较 68 镓（Ga-68）乙二胺四乙酸（EDTA）气溶胶和 Galligas 在评估有无阻塞性肺疾病的志愿者吸入颗粒沉积和清除方面的作用。
招募不吸烟的健康志愿者、健康吸烟者、哮喘患者和慢性阻塞性肺疾病（COPD）患者，在连续两天内进行动态肺通气正电子发射断层扫描/计算机断层扫描（PET/CT）扫描。吸入的颗粒分别为 Ga-68 标记的碳纳米颗粒（Galligas，粒径 30-60nm）和 Ga-68 标记的 EDTA 气溶胶（粒径 1-2μm）。比较志愿者的肺功能参数。
中央沉积和两种示踪剂的不均匀性与肺功能参数呈负相关，包括 1 秒用力呼气量与用力肺活量的比值（FEV/FVC）。Galligas 的中央或肺门沉积，但不是 68 镓（Ga-68）EDTA，与最大呼气流量在 25%、50%和 75%用力肺活量时呈负相关。与 Galligas 相比，除健康不吸烟者外，Ga-68 EDTA 气溶胶在所有组中更集中在中央区域。使用 Ga-68 EDTA 气溶胶时，通气不均匀性更为明显，尤其是在 COPD 患者和哮喘患者中。在健康吸烟者中，吸入后 30 分钟比吸入后立即，中央区域积聚更多的 Ga-68 EDTA。Ga-68 EDTA 在肺部的清除速度快于 Galligas。
Galligas 和 Ga-68 EDTA 气溶胶均可用于 PET/CT 肺通气扫描。然而，Ga-68 EDTA 气溶胶在揭示吸入颗粒沉积和清除方面显示出更多的优势，可用于诊断和评估阻塞性气道疾病。
