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异体骨软骨移植与半髁状异体骨移植术后结果无差异。

No Difference in Outcomes Following Osteochondral Allograft with Fresh Precut Cores Compared to Hemi-Condylar Allografts.

机构信息

Department of Orthopedic Surgery, New York University Langone Health, New York, NY, USA.

Department of Radiology, New York University Langone Health, New York, NY, USA.

出版信息

Cartilage. 2021 Dec;13(1_suppl):886S-893S. doi: 10.1177/19476035211021911. Epub 2021 Jun 2.

Abstract

OBJECTIVE

The purpose of the current study is to evaluate the clinical and radiographic outcomes at early to midterm follow-up between fresh precut cores versus hemi-condylar osteochondral allograft (OCAs) in the treatment of symptomatic osteochondral lesions.

DESIGN

A retrospective review of patients who underwent an OCA was performed. Patient matching between those with OCA harvested from an allograft condyle/patella or a fresh precut allograft core was performed to generate 2 comparable groups. The cartilage at the graft site was assessed with use of a modified Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scoring system and patient-reported outcomes were collected.

RESULTS

Overall, 52 total patients who underwent OCA with either fresh precut OCA cores ( = 26) and hemi-condylar OCA ( = 26) were pair matched at a mean follow-up of 34.0 months (range 12 months to 99 months). The mean ages were 31.5 ± 10.7 for fresh precut cores and 30.9 ± 9.8 for hemi-condylar ( = 0.673). Males accounted for 36.4% of the overall cohort, and the mean lesion size for fresh precut OCA core was 19.6 mm compared to 21.2 mm for whole condyle ( = 0.178). There was no significant difference in patient-reported outcomes including Visual Analogue Scale, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, and Tegner ( > 0.5 for each), or in MOCART score (69.2 vs. 68.3, = 0.93).

CONCLUSIONS

This study found that there was no difference in patient-reported clinical outcomes or MOCART scores following OCA implantation using fresh precut OCA cores or size matched condylar grafts at early to midterm follow-up.

摘要

目的

本研究旨在评估新鲜预切开骨芯与半髁骨软骨同种异体移植物(OCA)治疗症状性骨软骨病变的早期至中期随访时的临床和影像学结果。

设计

对接受 OCA 治疗的患者进行回顾性研究。对来自同种异体髁/髌骨或新鲜预切开同种异体骨芯的 OCA 患者进行匹配,以生成 2 个可比组。使用改良的磁共振观察软骨修复组织(MOCART)评分系统评估移植物部位的软骨,并收集患者报告的结果。

结果

总体而言,52 例患者接受 OCA 治疗,其中 26 例采用新鲜预切开 OCA 骨芯,26 例采用半髁 OCA,平均随访 34.0 个月(12 个月至 99 个月)。新鲜预切开骨芯组的平均年龄为 31.5 ± 10.7 岁,半髁组为 30.9 ± 9.8 岁(=0.673)。男性占总队列的 36.4%,新鲜预切开 OCA 骨芯的平均病变大小为 19.6mm,而整个髁的病变大小为 21.2mm(=0.178)。在患者报告的结果方面,包括视觉模拟评分、膝关节损伤和骨关节炎结果评分关节置换和 Tegner(每项 >0.5),或在 MOCART 评分(69.2 对 68.3,=0.93)方面,两组之间无显著差异。

结论

本研究发现,在早期至中期随访时,使用新鲜预切开 OCA 骨芯或大小匹配的髁状突移植物进行 OCA 植入后,患者报告的临床结果或 MOCART 评分无差异。

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