[突触核蛋白病中的睡眠障碍]

[Sleep disorders in synucleinopathy].

作者信息

Zakharov A V, Kalinin V A, Khivintseva E V

机构信息

Samara State Medical University, Samara, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(4. Vyp. 2):98-102. doi: 10.17116/jnevro202112104298.

DOI:10.17116/jnevro202112104298

PMID:34078867

Abstract

The article highlights the current state of the problem of sleep disorders in various neurodegenerative diseases. The clinical picture and diagnosis of these disorders are described in detail. Separately, the emphasis is made on the mechanisms underlying development of these disorders and their features in various forms of synucleinopathies. The mediator and physiological changes that underlie sleep disorders in various nosological units of synucleinopathies are discussed in detail. The current attitude to certain sleep disorders as predictors of neurodegenerative diseases is evaluated. The role of the glymphatic system in the development of these disorders is considered. Also, modern therapeutic strategies for sleep disorders in neurodegenerative diseases are discussed.

摘要

本文重点介绍了各种神经退行性疾病中睡眠障碍问题的现状。详细描述了这些障碍的临床表现和诊断。另外，着重阐述了这些障碍发生发展的机制及其在各种形式的突触核蛋白病中的特点。详细讨论了突触核蛋白病不同病种中睡眠障碍背后的介质和生理变化。评估了当前对某些睡眠障碍作为神经退行性疾病预测指标的看法。探讨了类淋巴系统在这些障碍发生发展中的作用。此外，还讨论了神经退行性疾病中睡眠障碍的现代治疗策略。