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血清素转运体启动子连锁多态性区域的多态性对开胸术后疼痛严重程度的影响。

Effects of Polymorphisms in the Serotonin Transporter Promoter-Linked Polymorphic Region on Postthoracotomy Pain Severity.

作者信息

Kimura Aya, Yamasaki Hiroyuki, Ishii Haruka, Yoshida Hisako, Shimizu Motoko, Mori Takashi

机构信息

Department of Anesthesiology, Osaka City University Graduate School of Medicine, Osaka City, Osaka, Japan.

Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka City, Osaka, Japan.

出版信息

J Pain Res. 2021 May 25;14:1389-1397. doi: 10.2147/JPR.S298685. eCollection 2021.

DOI:10.2147/JPR.S298685
PMID:34079356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8164694/
Abstract

PURPOSE

Serotonin (5-HT) is highly associated with pain modulation. The human 5-HT transporter (5-HTT) gene (SLC6A4) features several polymorphisms in its promoter region (5-HTTLPR) that affect the 5-HTT expression. The S allele of 5-HTTLPR induces low 5-HT tone, and it may influence the modulation of chronic pain. Meanwhile, pain occurs in 40-50% of patients after thoracic surgery, and its mechanism remains under investigation. This study assessed the role of 5-HTTLPR polymorphisms in postthoracotomy pain severity.

PATIENTS AND METHODS

A total of 178 patients undergoing pneumonectomy were enrolled. The genotypes of 5-HTTLPR were divided into two groups: S/S group and S/L or L/L group. Linear mixed-effects models were used to assess the association between 5-HTTLPR genotypes and the numerical rating scale (NRS) score change over time.

RESULTS

Among the participants, data were obtained for 162 patients. The genotype distribution was as follows: S/S, 67.3%; S/L or L/L, 32.7%. No significant difference in patient characteristics was found between the genotype groups. There was no significant interaction between the 5-HTTLPR genotypes and the NRS score change over time (p = 0.842).

CONCLUSION

Polymorphisms in 5-HTTLPR were not associated with postthoracotomy pain severity.

摘要

目的

血清素（5-羟色胺，5-HT）与疼痛调节高度相关。人类5-HT转运体（5-HTT）基因（SLC6A4）在其启动子区域（5-HTTLPR）具有多个多态性，这些多态性会影响5-HTT的表达。5-HTTLPR的S等位基因会导致5-HT水平降低，可能影响慢性疼痛的调节。同时，40%-50%的胸科手术后患者会出现疼痛，其机制仍在研究中。本研究评估了5-HTTLPR多态性在开胸术后疼痛严重程度中的作用。

患者与方法

共纳入178例行肺切除术的患者。5-HTTLPR的基因型分为两组：S/S组和S/L或L/L组。采用线性混合效应模型评估5-HTTLPR基因型与数值评定量表（NRS）评分随时间变化之间的关联。

结果

在参与者中，获得了162例患者的数据。基因型分布如下：S/S，67.3%；S/L或L/L，32.7%。基因型组之间患者特征无显著差异。5-HTTLPR基因型与NRS评分随时间的变化之间无显著交互作用（p = 0.842）。

结论

5-HTTLPR多态性与开胸术后疼痛严重程度无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/6c0579e91397/JPR-14-1389-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/6db5aa4c31d0/JPR-14-1389-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/2fa0822b29d5/JPR-14-1389-g0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/413f89d8568b/JPR-14-1389-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/6c0579e91397/JPR-14-1389-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/6db5aa4c31d0/JPR-14-1389-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/2fa0822b29d5/JPR-14-1389-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/d18c269fbcfa/JPR-14-1389-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/ff234face8e6/JPR-14-1389-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/413f89d8568b/JPR-14-1389-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50da/8164694/6c0579e91397/JPR-14-1389-g0006.jpg

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