Chopra A, Bansal R, Sharma N, Kulshreshtha B
"Dr. Ram Manohar Lohia" Hospital, Department of Endocrinology, New Delhi, India.
Acta Endocrinol (Buchar). 2020 Oct-Dec;16(4):497-500. doi: 10.4183/aeb.2020.497.
Ectopic parathyroid adenoma is an uncommon cause of primary hyperparathyroidism. Apart from the usually described sites of ectopic parathyroid adenoma, anecdotal case reports of undescended parathyroid adenoma along the carotid artery have been described.
We report a rare case of a 4 cm large parathyroid adenoma within the carotid sheath.
A 27-year-old lady presented with severe bony pains, history of height loss, fracture of left shaft femur following trivial trauma and renal calculi. On evaluation she had hypercalcemia with elevated iPTH suggestive of primary hyperparathyroidism. Ultrasound of neck and 99mTc sestamibi SPECT/CT incorrectly localised the lesion as right inferior parathyroid adenoma leading to a failed initial surgery. Later CECT of the neck identified adenoma posterior to right common carotid artery which was confirmed on repeat surgery and the patient was cured.
Ectopic parathyroid adenomas are both difficult to localise and are a common cause of failed initial parathyroid surgery. Surgeons should exercise caution while removing a visually normal parathyroid gland. In case of any discordance with the pre-operative localization, a meticulous systematic dissection using the conventional approach should be performed and the possibility of an undescended gland in the carotid sheath should be considered.
异位甲状旁腺腺瘤是原发性甲状旁腺功能亢进症的一种罕见病因。除了通常描述的异位甲状旁腺腺瘤的部位外,还曾有沿颈动脉出现未降入正常位置的甲状旁腺腺瘤的个案报道。
我们报告一例罕见病例,在颈动脉鞘内发现一个4厘米大的甲状旁腺腺瘤。
一名27岁女性患者出现严重骨痛、身高降低病史、轻微外伤后左股骨干骨折及肾结石。经评估,她存在高钙血症且iPTH升高,提示原发性甲状旁腺功能亢进症。颈部超声及99mTc甲氧基异丁基异腈单光子发射计算机断层扫描/计算机断层扫描(99mTc sestamibi SPECT/CT)将病变错误定位为右下甲状旁腺腺瘤,导致初次手术失败。后来颈部增强计算机断层扫描(CECT)发现右颈总动脉后方的腺瘤,再次手术得以证实,患者治愈。
异位甲状旁腺腺瘤既难以定位,也是初次甲状旁腺手术失败的常见原因。外科医生在切除外观正常的甲状旁腺时应谨慎行事。如果与术前定位不一致,应采用传统方法进行细致的系统解剖,并考虑颈动脉鞘内存在未降入正常位置腺体的可能性。