Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.
Department of Chemistry, The Women University Multan, Multan 60800, Pakistan.
Nanomedicine (Lond). 2021 Jul;16(16):1377-1390. doi: 10.2217/nnm-2021-0036. Epub 2021 Jun 4.
To optimize the Zinc oxide nanoparticles (ZnONPs)-catalyzed photolysis of bilirubin and to test their effect on bilirubin clearance . ZnONPs, synthesized in an alkaline medium, were characterized. Response surface methodology was used to optimize the photolysis catalyzed by the nanoparticles (NPs). Blood samples from phenylhydrazine-induced hyperbilirubinemic rabbits which had been administered ZnONPs and UV light were analyzed to assess clearance of bilirubin. The ZnONP-assisted UV treatment showed the linear and quadratic positive effects on the bilirubin photolysis with an optimal photolysis of bilirubin at 225 mg dl concentration of ZnONPs and a UV exposure of 1.80 h. The ZnONP-assisted phototherapy of hyperbilirubinemic animals was also found to be more effective for clearance of bilirubin than phototherapy alone. After further trials, ZnONP-assisted phototherapy could be a potential treatment for hyperbilirubinemia in humans.
为了优化氧化锌纳米粒子（ZnONPs）催化胆红素的光解，并测试其对胆红素清除的效果。合成了在碱性介质中的 ZnONPs，并对其进行了表征。采用响应面法优化了纳米粒子（NPs）催化的光解。对已给予 ZnONPs 和紫外线照射的苯肼诱导高胆红素血症兔的血液样本进行分析，以评估胆红素的清除率。ZnONP 辅助的 UV 处理对胆红素的光解具有线性和二次正效应，在 ZnONP 浓度为 225mg dl 和 UV 暴露 1.80h 时达到最佳胆红素光解。还发现 ZnONP 辅助的光疗对高胆红素血症动物的胆红素清除比单独光疗更有效。经过进一步试验，ZnONP 辅助的光疗可能成为人类高胆红素血症的一种潜在治疗方法。
