Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Elife. 2021 Jun 4;10:e66057. doi: 10.7554/eLife.66057.
Pathological oscillations including elevated beta activity in the subthalamic nucleus (STN) and between STN and cortical areas are a hallmark of neural activity in Parkinson's disease (PD). Oscillations also play an important role in normal physiological processes and serve distinct functional roles at different points in time. We characterised the effect of dopaminergic medication on oscillatory whole-brain networks in PD in a time-resolved manner by employing a hidden Markov model on combined STN local field potentials and magnetoencephalography (MEG) recordings from 17 PD patients. Dopaminergic medication led to coherence within the medial and orbitofrontal cortex in the delta/theta frequency range. This is in line with known side effects of dopamine treatment such as deteriorated executive functions in PD. In addition, dopamine caused the beta band activity to switch from an STN-mediated motor network to a frontoparietal-mediated one. In contrast, dopamine did not modify local STN-STN coherence in PD. STN-STN synchrony emerged both on and off medication. By providing electrophysiological evidence for the differential effects of dopaminergic medication on the discovered networks, our findings open further avenues for electrical and pharmacological interventions in PD.
病理性振荡，包括丘脑底核（STN）和 STN 与皮质区域之间的β活动升高，是帕金森病（PD）神经活动的标志。振荡在正常生理过程中也起着重要作用，并在不同时间点发挥不同的功能作用。我们采用隐马尔可夫模型对 17 名 PD 患者的 STN 局部场电位和脑磁图（MEG）记录进行了联合分析，以时间分辨的方式描述了多巴胺能药物对 PD 患者全脑振荡网络的影响。多巴胺能药物导致了 delta/theta 频带范围内内侧和眶额皮层内的相干性。这与多巴胺治疗的已知副作用一致，例如 PD 中的执行功能恶化。此外，多巴胺导致β频段活动从 STN 介导的运动网络切换到额顶叶介导的网络。相比之下，多巴胺并没有改变 PD 中 STN-STN 的相干性。STN-STN 同步在药物治疗和非药物治疗中都存在。通过为发现的网络中多巴胺能药物的差异作用提供电生理证据，我们的发现为 PD 的电和药物干预开辟了进一步的途径。
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