致癌长链非编码 RNA BCAR4 对癌症结局的功能作用。
The Functional Role of Oncogenic LncRNA BCAR4 for Cancer Outcome.
机构信息
College of Medical Science, China Three Gorges University, Yichang 443002, China.
出版信息
Curr Pharm Des. 2021;27(39):4107-4113. doi: 10.2174/1381612827666210604114955.
BACKGROUND
Long non-coding RNA (lncRNA) breast cancer anti-estrogen resistance 4 (BCAR4) is a characterized oncogenic lncRNA in different cancers. This review is dedicated to summarize various molecular mechanisms of BCAR4 and demonstrate that the biological functions exerted by BCAR4 are good entry points for therapy.
METHODS
The molecular mechanism of BCAR4 acting on tumors is summarized by reviewing PubMed.
RESULTS
The expression of lncRNA BCAR4 is abnormally increased in all kinds of tumors, including colorectal cancer, prostate cancer, bladder cancer, gastric cancer, chondrosarcoma, glioma, breast cancer, glioma, gastric cancer, liver cancer, cervical cancer, lung cancer, etc. Besides, BCAR4 mediates multiple processes involved in carcinogenesis, including proliferation, invasion, anti-apoptosis, migration.
CONCLUSION
BCAR4 may show great clinical value in this direction as a therapeutic cancer target.
背景
长链非编码 RNA（lncRNA）乳腺癌雌激素抵抗蛋白 4（BCAR4）是不同癌症中具有特征性致癌作用的 lncRNA。本综述旨在总结 BCAR4 的各种分子机制，并证明 BCAR4 发挥的生物学功能是治疗的良好切入点。
方法
通过查阅 PubMed 总结 BCAR4 作用于肿瘤的分子机制。
结果
lncRNA BCAR4 的表达在各种肿瘤中异常增加，包括结直肠癌、前列腺癌、膀胱癌、胃癌、软骨肉瘤、神经胶质瘤、乳腺癌、神经胶质瘤、胃癌、肝癌、宫颈癌、肺癌等。此外，BCAR4 介导涉及致癌作用的多个过程，包括增殖、侵袭、抗凋亡、迁移。
结论
BCAR4 作为一种治疗癌症的靶点，在这一方向上可能具有重要的临床价值。
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