Trufanov Artem, Bisaga Gennady, Skulyabin Dmitry, Temniy Alexandr, Poplyak Mariya, Chakchir Oleg, Efimtsev Aleksandr, Dmitriy Tarumov, Odinak Miroslav, Litvinenko Igor
Department of Nanobiotechnology, Autonomous Non-profit Higher Education Organization (University associated with the Interparliamentary Assembly of the Eurasian Economic Community), 14/1, letter B, Smolyachkova Street, 194044 Saint-Petersburg, Russia; Department of Neurology, Kirov Military Medical Academy, 6, Lebedeva Street, 194044 Saint-Petersburg, Russia.
Department of Neurology, Almazov National Medical Research Centre, 2, Akkuratova Street, 197341 Saint-Petersburg, Russia.
J Clin Neurosci. 2021 Jul;89:375-380. doi: 10.1016/j.jocn.2021.05.043. Epub 2021 Jun 2.
To define both the severity and extent of structural alteration in certain thalamic nuclei by means of MR morphometry and to compare these findings with clinical performance in different phenotypes of multiple sclerosis (MS).
We comparatively measured the thalamus nuclei volumes of patients with remitting-relapsing (RRMS) and secondary-progressive (SPMS) phenotypes of multiple sclerosis and healthy control subjects (HC). The evaluation of neurological performance was based on the results of Expanded Disability Status Scale and Multiple Sclerosis Severity Scale. Cognitive and mental state was rated according to the results of Mini-Mental State Examination, Frontal Assessment Battery, Montreal Cognitive Assessment and Symbol Digit Modalities Test. Freesurfer 6.0 was used for thalamic nuclei volumes calculation.
The median volume decline in thalamic pulvinar nuclei in RRMS group on the left side (anterior nucleus - 186,6 mm, posterior nucleus - 149,4 mm, medial nucleus 852,4 mm) compared to HC (anterior nucleus - 229,2 mm, posterior nucleus - 187,5 mm, medical nucleus - 1081,3 mm). Same group, right side - anterior nucleus - 219,5 mm, posterior nucleus 187,1 mm, medial nucleus - 989,6 mm; HC group - anterior nucleus 261,1 mm, posterior nucleus 240,5 mm, medial nucleus - 1196,7 mm (p < 0,05). The highest correlation of the written section of SDMT was observed with the left ventral anterior nucleus (r = 0,71).
These findings indicate the credible correlation between clinical progression of neurological and cognitive impairment in MS patients with asymmetry left-sided thalamic nuclei atrophy and may be considered a potential predicting tool of MS progression.
通过磁共振形态测量法确定某些丘脑核团结构改变的严重程度和范围，并将这些结果与多发性硬化症（MS）不同表型的临床表现进行比较。
我们比较测量了复发缓解型（RRMS）和继发进展型（SPMS）多发性硬化症患者以及健康对照者（HC）的丘脑核团体积。神经功能表现的评估基于扩展残疾状态量表和多发性硬化症严重程度量表的结果。认知和精神状态根据简易精神状态检查表、额叶评估量表、蒙特利尔认知评估量表和符号数字模式测验的结果进行评分。使用Freesurfer 6.0计算丘脑核团体积。
与健康对照者相比，RRMS组左侧丘脑枕核的体积中位数下降（前核 - 186.6立方毫米，后核 - 149.4立方毫米，内侧核 - 852.4立方毫米）（健康对照者：前核 - 229.2立方毫米，后核 - 187.5立方毫米，内侧核 - 1081.3立方毫米）。同一组，右侧 - 前核 - 219.5立方毫米，后核 - 187.1立方毫米，内侧核 - 989.6立方毫米；健康对照组 - 前核 - 261.1立方毫米，后核 - 240.5立方毫米，内侧核 - 1196.7立方毫米（p < 0.05）。观察到符号数字模式测验书面部分与左侧腹前核的相关性最高（r = 0.71）。
这些发现表明，左侧丘脑核团不对称萎缩的MS患者神经和认知功能障碍的临床进展之间存在可靠的相关性，并可被视为MS进展的潜在预测工具。
