衰老对大鼠骨骼肌基底膜相关基因表达的影响。
Effects of aging on basement membrane-related gene expression of the skeletal muscle in rats.
机构信息
Department of Medical Technology and Clinical Engineering, Hokuriku University.
Department of Anatomy and Neurobiology, Graduate school of Medical Sciences, Kindai University.
出版信息
Biomed Res. 2021;42(3):115-119. doi: 10.2220/biomedres.42.115.
The basement membrane (BM), with collagen IV as a major component, plays an important role in the maintenance of muscle structure and its robustness. To investigate the effects of aging on factors related to BM construction, we compared the expression status of these factors in 3- and 20-month-old male Wistar rats. The expression levels of Col4a1 and Col4a2 (encoding collagen IV), Sparc (involved in collagen IV functionalization), and Mmp14 (a collagen IV degradation factor) were decreased. These results suggest that aging suppresses collagen IV synthetic and degradative factors and affects BM-related factors in the steady state.
基底层（BM）以胶原蛋白 IV 为主要成分，在维持肌肉结构及其坚固性方面发挥着重要作用。为了研究衰老对与 BM 构建相关的因素的影响，我们比较了 3 月龄和 20 月龄雄性 Wistar 大鼠中这些因素的表达状态。Col4a1 和 Col4a2（编码胶原蛋白 IV）、Sparc（参与胶原蛋白 IV 功能化）和 Mmp14（胶原蛋白 IV 降解因子）的表达水平降低。这些结果表明，衰老抑制了胶原蛋白 IV 的合成和降解因子，并影响了稳定状态下与 BM 相关的因素。
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