Fukao K, Tanimoto Y, Kayata Y, Yoshiga K, Takada K, Okuda K
Department of Oral and Maxillofacial Surgery, Hiroshima University, School of Dentistry, Japan.
Carcinogenesis. 1988 Sep;9(9):1661-4. doi: 10.1093/carcin/9.9.1661.
Fluocinolone acetonide (FA) is one of the most potent synthetic glucocorticoids and is known to possess an anti-tumor promoting activity. An attempt was made to evaluate this activity by estimating tumor promoting activity. Unexpectedly, when 10 micrograms of FA was applied alone or after a single application of a subcarcinogenic dose of 3-methylcholanthrene to mouse skin, results suggested that FA itself may be a tumor promoter or a complete carcinogen. Other glucocorticoids tested, e.g. dexamethasone, hydrocortisone and prednisolone, also revealed similar effects but were less potent than FA. To verify the possibility that glucocorticoid is a complete carcinogen or a tumor promoter, a tumor incidence experiment was performed for 24 weeks. As a result it was found that FA possesses a tumor promoting activity at some dose levels but no tumor initiating activity.
醋酸氟轻松（FA）是最有效的合成糖皮质激素之一，已知具有抗肿瘤促进活性。人们试图通过评估肿瘤促进活性来评价这种活性。出乎意料的是，当单独应用10微克FA或在对小鼠皮肤单次给予亚致癌剂量的3-甲基胆蒽后应用FA时，结果表明FA本身可能是一种肿瘤促进剂或完全致癌物。所测试的其他糖皮质激素，如地塞米松、氢化可的松和泼尼松龙，也显示出类似的效果，但效力低于FA。为了验证糖皮质激素是完全致癌物或肿瘤促进剂的可能性，进行了为期24周的肿瘤发生率实验。结果发现，FA在某些剂量水平具有肿瘤促进活性，但没有肿瘤启动活性。
