神经母细胞瘤中 RAS-MAPK 通路改变的生物学和临床意义的综述。
A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma.
机构信息
CANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, University of Geneva, Avenue de la Roseraie 64, 1205, Geneva, Switzerland.
Division of Pediatric Oncology and Hematology, Department of Women, Child and Adolescent, University Hospital of Geneva, Rue Willy-Donzé 6, 1205, Geneva, Switzerland.
出版信息
J Exp Clin Cancer Res. 2021 Jun 8;40(1):189. doi: 10.1186/s13046-021-01967-x.
Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway's contribution to the development and progression of neuroblastoma. This review compiles up-to-date evidence of this pathway's involvement in neuroblastoma. We discuss the RAS-MAPK pathway's general functioning, the clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling.
神经母细胞瘤是儿童最常见的颅外实体瘤，约占所有儿童恶性肿瘤的 8%，占儿童癌症相关死亡的 15%。最近的测序和转录组学研究表明，RAS-MAPK 通路参与了神经母细胞瘤的发生和发展。本综述汇总了该通路在神经母细胞瘤中作用的最新证据。我们讨论了 RAS-MAPK 通路的一般功能，其在神经母细胞瘤中失调的临床意义，以及目前针对信号转导相关蛋白的有前途的治疗方法。
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