Perlmutter A, Potter H
Laboratory of Aquatic Biology, New York University, New York 10003.
J Cancer Res Clin Oncol. 1988;114(4):359-62. doi: 10.1007/BF02128178.
In fishes of the genus Xiphophorus, hybrid offspring of the spotted dorsal female platyfish, X. maculatus, and male swordtails, X. helleri, are genetically programmed to develop melanoma when raised at ambient laboratory temperatures. When these hybrid offspring were raised under hyperthermic conditions, there was no development of melanoma. Electron microscopy revealed degenerative changes in the melanocytes of heat-treated hybrids not seen in hybrids raised at ambient temperatures. The platyfish-swordtail melanoma system represents an appropriate model for the investigation of the relationship between hyperthermia and melanoma formation and treatment in poikilothermic vertebrates.
在剑尾鱼属鱼类中，斑点背鳍雌鱼新月剑尾鱼（X. maculatus）与雄剑尾鱼（X. helleri）的杂交后代，在实验室环境温度下饲养时，基因决定会患上黑色素瘤。当这些杂交后代在高温条件下饲养时，则不会发生黑色素瘤。电子显微镜检查显示，经热处理的杂交后代的黑素细胞出现了退行性变化，而在环境温度下饲养的杂交后代中未观察到这种变化。新月剑尾鱼 - 剑尾鱼黑色素瘤系统是研究变温脊椎动物热疗与黑色素瘤形成及治疗之间关系的合适模型。
