Gerontology Department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Brussels, Belgium; Frailty in Ageing (FRIA) Research Department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Brussels, Belgium.
Frailty in Ageing (FRIA) Research Department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Brussels, Belgium; Department of Geriatrics, Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, B-1090 Brussels, Belgium.
Exp Gerontol. 2021 Sep;152:111440. doi: 10.1016/j.exger.2021.111440. Epub 2021 Jun 9.
INTRODUCTION: Low grip work and high feelings of self-perceived fatigue could be an early characteristic of decline in reserve capacity, which comes to full expression as physical frailty in a later stage. When grip work and self-perceived fatigue can be identified as characteristics differentiating between robustness and pre-frailty it might allow to identify pre-frailty earlier. Therefore, this study aimed to investigate whether the combination of grip work and self-perceived fatigue is related to pre-frailty in well-functioning older adults aged 80 and over. METHODS: Four-hundred and five community-dwelling older adults aged 80 and over (214 robust and 191 pre-frail) were assessed for muscle endurance (grip Work corrected for body weight (GW_bw)), self-perceived fatigue (MFI-20) and frailty state (Fried Frailty Index, FFI). A Capacity to Perceived Vitality ratio (CPV) was calculated by dividing GW_bw by the MFI-20 scores. ANCOVA analysis (corrected for age and gender) was used to compare robust and pre-frail older adults, and binary logistic regressions were applied to analyze the relationship between CPV and pre-frailty status. RESULTS: Pre-frail older adults who scored negative on the exhaustion item of the FFI still showed significantly lower GW (p < 0.001), CPV ratios (p < 0.001) and higher self-perceived fatigue (p < 0.05) compared to the robust ones. The likelihood for pre-frailty related significantly to higher age, being men and lower CPV ratios. In women, every unit increase in CPV ratio decreased the likelihood for pre-frailty by 78% (OR 0.22; 95% CI: 0.11-0.44), for men this effect was less strong (34%, OR 0.66; 95% CI: 0.47-0.93). CONCLUSIONS: Pre-frail community-dwelling persons aged 80 years and over without clinical signs of exhaustion on the FFI still experience significantly higher fatigue levels (lower Grip Work, higher self-perceived fatigue and lower CPV levels) compared to robust ones. CPV ratio could therefore be a good tool to identify subclinical fatigue in the context of physical (pre-)frailty.
简介：低握力工作和高自我感知疲劳可能是储备能力下降的早期特征，而在后期则完全表现为身体虚弱。当握力工作和自我感知疲劳可以被识别为区分稳健性和衰弱前期的特征时，它可能会更早地识别出衰弱前期。因此，本研究旨在探讨在 80 岁及以上功能良好的老年人中，握力工作和自我感知疲劳的组合是否与衰弱前期有关。 方法：评估了 405 名社区居住的 80 岁及以上老年人（214 名稳健和 191 名衰弱前期）的肌肉耐力（握力工作校正后的体重（GW_bw））、自我感知疲劳（MFI-20）和衰弱状态（Fried 衰弱指数，FFI）。通过将 GW_bw 除以 MFI-20 评分，计算出一个感知活力比（CPV）。采用协方差分析（校正年龄和性别）比较稳健和衰弱前期老年人，应用二元逻辑回归分析 CPV 与衰弱前期状态的关系。 结果：在 FFI 中对疲惫项回答为否的衰弱前期老年人，其 GW（p<0.001）、CPV 比值（p<0.001）仍显著降低，自我感知疲劳（p<0.05）仍显著升高。衰弱前期与年龄较高、男性和 CPV 比值较低显著相关。在女性中，CPV 比值每增加一个单位，衰弱前期的可能性就会降低 78%（OR 0.22；95% CI：0.11-0.44），而男性的效果较弱（34%，OR 0.66；95% CI：0.47-0.93）。 结论：在 FFI 上没有表现出疲惫迹象的 80 岁及以上衰弱前期社区居住者，与稳健者相比，仍经历着更高的疲劳水平（更低的握力工作、更高的自我感知疲劳和更低的 CPV 水平）。因此，CPV 比值可以作为识别身体（衰弱前期）相关亚临床疲劳的一个良好工具。
Int J Environ Res Public Health. 2023-8-16
Aging Clin Exp Res. 2022-9
Arch Gerontol Geriatr. 2017-10-28
J Nutr Health Aging. 2020
Int J Environ Res Public Health. 2023-8-16
Lancet Healthy Longev. 2022-11
Zotero 插件