齐多夫定增强碳青霉烯类药物对产 NDM-1 的肠杆菌科的活性。
Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae.
机构信息
Institute for Infection and Immunity, St George's University of London, London, UK.
Helperby Therapeutics Group plc, London, UK.
出版信息
J Antimicrob Chemother. 2021 Aug 12;76(9):2302-2305. doi: 10.1093/jac/dkab184.
OBJECTIVES
To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae.
METHODS
MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time-kill analysis.
RESULTS
We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time-kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem.
CONCLUSIONS
Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.
目的
研究齐多夫定联合碳青霉烯类药物对产 NDM-1 肠杆菌科细菌的疗效。
方法
采用肉汤微量稀释法测定 MIC。采用棋盘法和时间杀伤分析检测齐多夫定和碳青霉烯类药物的联合效应。
结果
我们发现产 NDM-1 菌株对所有测试的碳青霉烯类药物均耐药。棋盘试验的 FIC 指数表明，齐多夫定与碳青霉烯类药物联合使用对所有 NDM-1 菌株均具有协同作用。时间杀伤分析表明，当低水平的齐多夫定与美罗培南联合使用时，具有显著的协同活性。
结论
齐多夫定联合碳青霉烯类药物对产 NDM-1 肠杆菌科细菌具有体外协同作用。
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