Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, India.
Environ Sci Pollut Res Int. 2021 Aug;28(32):43021-43034. doi: 10.1007/s11356-021-14884-5. Epub 2021 Jun 14.
Omega-3 fatty acids have been acknowledged for their number of holdings on an individual's health. Not only in physical valuation but also in managing psychiatric disorders, omega-3 fatty acids have been found to be a powerful formula. It is proclaimed that depressive patients suffer anomaly with the levels of omega-3 polyunsaturated fatty acids in the body, coupled with insignificant EPA and DHA. Enhancement in brain functioning, neuronal functions, and paying attention in interacting with the brain cells are some of the additional tasks, being performed by the supplementation of omega-3 fatty acids. The leading and primary source via dietary supplementation involves the involvement of fish and fish products. These are hypothesized to be the best and dominant source for omega-3 fatty acids. Consumption of omega-3 fatty acid is well safe, that physician highly favors intake of these supplements, remarkably in the case of pregnant women. However, treating this serious life-threatening mental disorder leads to many adverse effects when treated with antidepressants. The dose range includes 1g/d to 10g/d, which is to be incorporated by the patient. It is also tested that the combination of EPA and DHA is found to be more efficacious for a person in treating and preventing depressive symptoms. Some studies verify the supplementation of omega-3 fatty acids in diet was coequally productive and successful with minimal side effects when analyzed with antidepressants. Despite these facts, much research is still needed and presently in process for long-term safety and studying the role of omega-3 fatty acids in human health.
ω-3 脂肪酸因其对个体健康的诸多益处而备受认可。不仅在身体评估方面,在精神疾病的管理方面,ω-3 脂肪酸也被证明是一种有效的配方。有研究表明,抑郁患者体内 ω-3 多不饱和脂肪酸水平异常,同时 EPA 和 DHA 含量也较低。ω-3 脂肪酸的补充可以增强大脑功能、神经元功能,并有助于与脑细胞的相互作用。此外,ω-3 脂肪酸还可以促进大脑的正常运转,增加神经元的活跃度,提高注意力。通过饮食补充,ω-3 脂肪酸的主要来源是鱼类和鱼类产品。这些被认为是 ω-3 脂肪酸的最佳和主要来源。ω-3 脂肪酸的摄入非常安全,医生非常支持患者摄入这些补充剂,尤其是孕妇。然而,在治疗这种严重的危及生命的精神障碍时,抗抑郁药的治疗会带来许多不良反应。推荐的剂量范围为 1g/d 至 10g/d,患者应按此剂量服用。研究还发现,EPA 和 DHA 的联合使用在治疗和预防抑郁症状方面更有效。一些研究证实,ω-3 脂肪酸的补充与抗抑郁药同样有效且副作用较小。尽管有这些事实,但仍需要进行更多的研究,以确定 ω-3 脂肪酸在人类健康中的长期安全性和作用。