Song Guoda, Wang Min, Chen Bingliang, Long Gongwei, Li Hao, Li Rui, Liu Zhuo, Wei Chao, Wang Tao, Wang Shaogang, Liu Jihong, Zhang Yucong, Liu Xiaming
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Second Clinical College, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Med (Lausanne). 2021 May 28;8:653510. doi: 10.3389/fmed.2021.653510. eCollection 2021.
An association between lower urinary tract symptoms (LUTS) and risk of sexual dysfunction in male remains controversial in recent decades. PubMed and Web of Science were searched up to October 28, 2020, for articles reporting the prevalence of sexual dysfunction in men with LUTS. The main outcomes were results from sexual dysfunction assessments. Pooled odds ratio (OR) and weighted mean difference (WMD) with 95% confidence interval (CI) were calculated. The quality assessment of the included studies was performed by using The Newcastle-Ottawa Scale (NOS) or JBI Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI). A total of 24 full-manuscript papers met the inclusion criteria. The pooled OR for 21 studies suggested that patients with severer LUTS had a higher risk of sexual dysfunction (OR = 3.31, 95% CI: 2.43 to 4.49, < 0.001, = 90%). A significant decrease in scores of assessment tools for sexual dysfunction was observed in the patients with higher severity of LUTS compared with those patients with lower severity (WMD = -5.49, 95%CI: -7.25 to -3.27, P < 0.001, = 96%). Similar outcomes were also found in subgroup analyses. In a detailed analysis of specific sexual function domains, the severity of LUTS was associated with erectile dysfunction, intercourse satisfaction, and overall satisfaction, except for sexual desire. The study demonstrates an association between exposure of lower urinary tract symptoms and risk of sexual dysfunction in male. Assessment of sexual function is necessary for patients with lower urinary tract symptoms. http://www.crd.york.ac.uk/prospero, identifier: CRD42020208747.
近几十年来，男性下尿路症状（LUTS）与性功能障碍风险之间的关联一直存在争议。截至2020年10月28日，检索了PubMed和Web of Science，以查找报告LUTS男性性功能障碍患病率的文章。主要结果是性功能障碍评估的结果。计算了合并比值比（OR）和加权平均差（WMD）以及95%置信区间（CI）。采用纽卡斯尔-渥太华量表（NOS）或JBI统计评估与综述工具的荟萃分析（JBI-MAStARI）对纳入研究进行质量评估。共有24篇全文论文符合纳入标准。21项研究的合并OR表明，LUTS较严重的患者性功能障碍风险更高（OR = 3.31，95%CI：2.43至4.49，P < 0.001，I² = 90%）。与LUTS严重程度较低的患者相比，LUTS严重程度较高的患者性功能障碍评估工具的得分显著降低（WMD = -5.49，95%CI：-7.25至-3.27，P < 0.001，I² = 96%）。亚组分析也发现了类似的结果。在对特定性功能领域的详细分析中，除性欲外，LUTS的严重程度与勃起功能障碍、性交满意度和总体满意度相关。该研究表明男性下尿路症状暴露与性功能障碍风险之间存在关联。对于下尿路症状患者，有必要进行性功能评估。http://www.crd.york.ac.uk/prospero，标识符：CRD42020208747
