Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Br J Pharmacol. 2022 Mar;179(5):748-769. doi: 10.1111/bph.15591. Epub 2021 Jul 18.
Diabetes is a chronic metabolic disorder associated with the accelerated development of macrovascular (atherosclerosis and coronary artery disease) and microvascular complications (nephropathy, retinopathy and neuropathy), which remain the principal cause of mortality and morbidity in this population. Current understanding of cellular and molecular pathways of diabetes-driven vascular complications, as well as therapeutic interventions has arisen from studying disease pathogenesis in animal models. Diabetes-associated vascular complications are multi-faceted, involving the interaction between various cellular and molecular pathways. Thus, the choice of an appropriate animal model to study vascular pathogenesis is important in our quest to identify innovative and mechanism-based targeted therapies to reduce the burden of diabetic complications. Herein, we provide up-to-date information on available mouse models of both Type 1 and Type 2 diabetic vascular complications as well as experimental analysis and research outputs. LINKED ARTICLES: This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc.
糖尿病是一种与大血管(动脉粥样硬化和冠状动脉疾病)和微血管并发症(肾病、视网膜病变和神经病变)加速发展相关的慢性代谢性疾病,这些仍然是该人群死亡和发病的主要原因。目前对糖尿病驱动的血管并发症的细胞和分子途径以及治疗干预的理解,源于在动物模型中研究疾病发病机制。与糖尿病相关的血管并发症是多方面的,涉及各种细胞和分子途径的相互作用。因此,选择合适的动物模型来研究血管发病机制对于我们寻找创新的、基于机制的靶向治疗方法以减轻糖尿病并发症的负担非常重要。本文提供了有关 1 型和 2 型糖尿病血管并发症的现有小鼠模型的最新信息,以及实验分析和研究结果。相关文章:本文是心血管疾病研究的临床前模型专题的一部分(BJP 75 周年纪念)。要查看本节中的其他文章,请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc.