Departments of Epidemiology & Population Health and Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Dialyze Direct, Neptune City, New Jersey, USA.
Hemodial Int. 2021 Oct;25(4):548-559. doi: 10.1111/hdi.12943. Epub 2021 Jun 16.
Dialysis patients are often discharged from hospitals to skilled nursing facilities (SNFs), but little has been published about their natural history.
Using electronic medical record data, we conducted a retrospective cohort study of nursing home patients treated with in-SNF hemodialysis from January 1, 2018 through June 20, 2020 within a dialysis organization across eight states. A dialytic episode began with the first in-SNF dialysis and was ended by hospitalization, death, transfer, or cessation of treatment. The clinical characteristics and natural history of these patients and their dialytic episodes are described.
Four thousand five hundred and ten patients experienced 9274 dialytic episodes. Dialytic episodes had a median duration of 18 days (IQR: 8-38) and were terminated by a hospitalization n = 5747 (62%), transfer n = 2638 (28%), death n = 568 (6%), dialysis withdrawal n = 129 (1.4%), recovered function n = 2 (0.02%), or other cause n = 6 (0.06%). Increased patient mortality was associated with advancing age, low serum creatinine, albumin, or sodium, and low pre-dialytic systolic blood pressure (sBP). U-shaped relationships to mortality were observed for intradialytic hypotension frequency and for post- > pre-hemodialysis sBP frequency. Prescription of dialysis five times weekly in the first 2 weeks was associated with better survival in the first 90 days (HR 0.77, CI 0.62-0.96; p < 0.02).
Provision of in-SNF dialysis by an external dialysis organization enables discharge from the acute care setting for appropriate treatment with increased nursing contact time in an otherwise under-resourced environment. SNF ESRD patient clinical characteristics and outcomes are extensively characterized for the first time.
透析患者经常从医院出院到熟练护理机构(SNF),但关于他们的自然病史的研究却很少。
我们使用电子病历数据,对 2018 年 1 月 1 日至 2020 年 6 月 20 日期间在一个跨越八个州的透析组织内接受 SNF 内血液透析的疗养院患者进行了回顾性队列研究。透析阶段始于首次 SNF 透析,并因住院、死亡、转移或停止治疗而结束。描述了这些患者及其透析阶段的临床特征和自然病史。
4510 名患者经历了 9274 次透析阶段。透析阶段的中位持续时间为 18 天(IQR:8-38),以住院 n = 5747(62%)、转移 n = 2638(28%)、死亡 n = 568(6%)、透析退出 n = 129(1.4%)、功能恢复 n = 2(0.02%)或其他原因 n = 6(0.06%)终止。患者死亡率随着年龄的增加、血清肌酐、白蛋白或钠水平降低以及透析前收缩压(sBP)降低而增加。透析中低血压频率和透析前-后 sBP 频率之间观察到 U 型关系与死亡率相关。在最初的 2 周内每周透析 5 次与前 90 天的生存获益相关(HR 0.77,CI 0.62-0.96;p<0.02)。
外部透析组织提供的 SNF 内透析使患者能够从急性护理环境中出院,在资源不足的环境中增加护理接触时间,进行适当的治疗。首次对 SNF 终末期肾病患者的临床特征和结局进行了广泛描述。