通过光诱导从羧酸合成β-磺酰亚胺。
Photo-induced synthesis of β-sulfonyl imides from carboxylic acids.
作者信息
Zeng Linwei, Jin Jian, He Jixiao, Cui Sunliang
机构信息
Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
Chem Commun (Camb). 2021 Jul 8;57(55):6792-6795. doi: 10.1039/d1cc02559g.
A photo-induced imidation process of carboxylic acids is described. Numerous carboxylic acids could convert to β-sulfonyl imides in the presence of N-sulfonyl ynamides under visible light irradiation. Control experiments and mechanistic studies demonstrate that this imidation process involves a hydroacyloxylation/radical rearrangement cascade. This protocol represents a direct imidation method from carboxylic acids under mild conditions, with broad scope and high atom-economy.
描述了一种羧酸的光诱导酰亚胺化过程。在可见光照射下，许多羧酸在N-磺酰基烯炔酰胺存在下可转化为β-磺酰基酰亚胺。对照实验和机理研究表明，该酰亚胺化过程涉及氢酰氧基化/自由基重排级联反应。该方法代表了一种在温和条件下由羧酸直接进行酰亚胺化的方法，具有广泛的适用范围和高原子经济性。
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