Department of Neurology, Tsubame Rosai Hospital, Japan.
Department of Pathology, Brain Research Institute, Niigata University, Japan.
Intern Med. 2021 Dec 1;60(23):3809-3816. doi: 10.2169/internalmedicine.6717-20. Epub 2021 Jun 19.
Intravascular large B-cell lymphoma (IVLBCL) is a subtype of B-cell lymphoma, characterized by lymphoma cell proliferation within small blood vessels. We herein describe a rare case with long spinal cord lesions caused by venous congestive myelopathy associated with IVLBCL. An 81-year-old man presented with paraplegia of the lower limbs and sensory disturbances. Magnetic resonance imaging revealed intramedullary longitudinal T2-hyperintensity lesions in the thoracic cords. The patient died three months after disease onset, and a neuropathological analysis revealed predominantly atypical B-lymphocytes located sparsely in the veins of the spinal cord. IVLBCL should be considered in the differential diagnoses of long spinal cord lesions.
血管内大 B 细胞淋巴瘤（IVLBCL）是 B 细胞淋巴瘤的一种亚型，其特征是淋巴瘤细胞在小血管内增殖。本文描述了一例罕见病例，该患者因静脉性充血性脊髓病伴 IVLBCL 而导致长脊髓病变。一名 81 岁男性因下肢截瘫和感觉障碍就诊。磁共振成像显示胸髓内长 T2 高信号病变。患者自发病后 3 个月死亡，神经病理学分析显示主要为非典型 B 淋巴细胞，稀疏分布于脊髓静脉内。在鉴别诊断长脊髓病变时应考虑 IVLBCL。
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