孕期诊断为无纤维蛋白原血症，经靶向冷沉淀输血成功治疗：一例报告
Afibrinogenemia Diagnosed During Pregnancy Successfully Managed with Targeted Cryoprecipitate Transfusion: A Case Report.
作者信息
Shajan Athulya, George Neetha, Gilvaz Sareena, Abraham Siju V
机构信息
Department of Obstetrics and Gynaecology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala India.
Department of Emergency Medicine, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala India.
出版信息
J Obstet Gynaecol India. 2021 Apr;71(2):191-196. doi: 10.1007/s13224-020-01389-3. Epub 2020 Nov 17.
BACKGROUND
We report a case of afibrinogenemia in a lady, which was detected for the first time during her pregnancy.
CASE
A 24-year-old G4A3 was referred as a case of vaginal bleeding, after a cervical cerclage at 14 weeks of gestation. Elastometry targeted correction of coagulopathy was done initially, and targeted cryoprecipitate transfusion was done to maintain her gestation. She underwent induced vaginal delivery at 34 weeks of gestation. Fourteen days postpartum, the mother and child were discharged home well.
CONCLUSION
Coagulation factor deficiency should be considered as a rare cause for RPL. Serum fibrinogen level of 50-100 mg/dl during pregnancy seems to be a safe and adequate target to maintain in pregnant patients with afibrinogenemia.
背景
我们报告一例女性无纤维蛋白原血症病例，该病例在其孕期首次被检测出。
病例
一名24岁、孕4产3的女性在妊娠14周接受宫颈环扎术后，因阴道出血前来就诊。最初进行了弹性测定法以针对性纠正凝血障碍，并进行了针对性冷沉淀输血以维持妊娠。她在妊娠34周时接受了引产。产后14天，母婴均顺利出院回家。
结论
凝血因子缺乏应被视为复发性流产（RPL）的罕见原因。对于无纤维蛋白原血症的孕妇，孕期血清纤维蛋白原水平维持在50 - 100mg/dl似乎是一个安全且合适的目标。
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