Department of Medical Education, Taichung Veterans General Hospital, Taichung, 407, Taiwan.
School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Eye (Lond). 2022 Jun;36(6):1288-1293. doi: 10.1038/s41433-021-01645-4. Epub 2021 Jun 21.
To investigate the potential association between uveitis and an increased risk of developing inflammatory bowel disease (IBD).
We conducted a retrospective cohort study by interrogating data from the Taiwan National Health Insurance Research Database entered between January 1, 2001 and December 31, 2013 to identify uveitis patients and age- and gender-matched controls. The cumulative incidence rates of subsequent IBD in the two groups were compared. The adjusted hazard ratio (HR) of IBD related to uveitis was generated by a multivariate cox regression model after adjustment for hypertension, diabetes, hyperlipidaemia, obesity and smoking. Furthermore, the HRs of the Crohn's disease (CD) and ulcerative colitis (UC) IBD subtypes were calculated separately.
A total of 198,923 subjects with uveitis and 397,846 controls were enroled. The mean age of the cohort was 47.7 ± 18.9 years. A significantly higher cumulative incidence of IBD was found in the uveitis group than in controls (4.13% vs. 1.48%, p < 0.0001). Under univariate cox regression analysis, uveitis patients had a significantly higher risk of IBD (HR = 1.47; 95% confidence interval (CI): 1.43-1.52, p < 0.0001). The association remained significant in the multivariate regression model, with an adjusted HR of 1.44 (95% CI: 1.39-1.49, p < 0.0001). Moreover, in subgroup analysis, uveitis was significantly associated with an increased risk of Crohn's disease (adjusted HR = 1.49; 95% CI: 1.44-1.54), but not with ulcerative colitis (adjusted HR = 1.03; 95% CI: 0.92-1.15).
Patients with uveitis are at significantly greater risk of developing IBD than individuals without uveitis.
探讨葡萄膜炎与炎症性肠病（IBD）风险增加之间的潜在关联。
我们通过查询 2001 年 1 月 1 日至 2013 年 12 月 31 日期间台湾全民健康保险研究数据库中的数据，进行了一项回顾性队列研究，以确定葡萄膜炎患者和年龄、性别匹配的对照组。比较两组中随后发生 IBD 的累积发生率。使用多元 Cox 回归模型对高血压、糖尿病、高脂血症、肥胖和吸烟进行调整后，生成与葡萄膜炎相关的 IBD 的调整后的危险比（HR）。此外，还分别计算了克罗恩病（CD）和溃疡性结肠炎（UC）IBD 亚型的 HR。
共纳入 198923 例葡萄膜炎患者和 397846 例对照。队列的平均年龄为 47.7±18.9 岁。葡萄膜炎组的 IBD 累积发生率明显高于对照组（4.13%比 1.48%，p<0.0001）。在单因素 Cox 回归分析中，葡萄膜炎患者发生 IBD 的风险显著较高（HR=1.47；95%置信区间（CI）：1.43-1.52，p<0.0001）。在多变量回归模型中，这种关联仍然显著，调整后的 HR 为 1.44（95%CI：1.39-1.49，p<0.0001）。此外，在亚组分析中，葡萄膜炎与克罗恩病（调整后 HR=1.49；95%CI：1.44-1.54）的发生风险显著增加相关，但与溃疡性结肠炎（调整后 HR=1.03；95%CI：0.92-1.15）无关。
与没有葡萄膜炎的个体相比，患有葡萄膜炎的患者发生 IBD 的风险显著更高。
