Specificity of a nucleolar 2'-O-methyltransferase for RNA substrates.
作者信息
Eichler D C, Eales S J
机构信息
Department of Biochemistry, College of Medicine, University of South Florida, Tampa 33612.
出版信息
Biochem Biophys Res Commun. 1988 Aug 30;155(1):530-7. doi: 10.1016/s0006-291x(88)81119-7.
PMID:3415705
Abstract
In this study we examined the specificity of a nucleolar 2'-O-methyltransferase isolated from nucleoli of Ehrlich ascites tumor cells. The nucleolar methyltransferase was capable of methylating each of the four nucleosides of RNA, however, the level of methylation at a particular nucleoside varied with the type of RNA. Both kinetic analysis and the stimulation of methylation by polyamines suggested that the structure of RNA was critical in influencing the discrimination and apparent specificity of nucleolar 2'-O-methyltransferase.
摘要
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