Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Int J Antimicrob Agents. 2021 Sep;58(3):106383. doi: 10.1016/j.ijantimicag.2021.106383. Epub 2021 Jun 19.
Hepatitis E virus (HEV) infection in immunocompromised patients, pregnant women and children requires treatment; however, no approved medication is currently available. The macrolide antibiotic azithromycin has been identified as a potent HEV inhibitor. Azithromycin inhibits HEV replication and viral protein expression in multiple cell culture models with genotype 1 and 3 strains. This is largely independent of its induction of an interferon-like response. Because it is safe and cheap, repurposing azithromycin for treating HEV infection is attractive, particularly in resource-limited settings.
免疫功能低下患者、孕妇和儿童的戊型肝炎病毒（HEV）感染需要治疗；然而，目前尚无批准的药物。大环内酯类抗生素阿奇霉素已被确定为一种有效的 HEV 抑制剂。阿奇霉素在多种细胞培养模型中抑制基因型 1 和 3 株的 HEV 复制和病毒蛋白表达。这在很大程度上与其诱导干扰素样反应无关。由于阿奇霉素安全且廉价，将其重新用于治疗 HEV 感染具有吸引力，特别是在资源有限的环境中。
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