美国印第安老年人 binge drinking 与血管性脑损伤和萎缩的关联：“强壮心脏研究”。
Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study.
机构信息
WWAMI School of Medical Education, College of Health, 3291University of Alaska Anchorage, Anchorage, AK, USA.
Institute for Research and Education to Advance Community Health, 6760Washington State University, Seattle, WA, USA.
出版信息
J Aging Health. 2021 Aug-Sep;33(7-8_suppl):51S-59S. doi: 10.1177/08982643211013696.
American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.
美国印第安人（AIs）的饮酒量一般低于美国总人口，但酗酒障碍的患病率更高。这是第一项大规模队列研究，旨在探讨 binge drinking 是否是血管性脑损伤（VBI）的风险因素。我们使用线性和泊松回归分析，研究了 817 名参与 Strong Heart 和 American Indians 研究的老年人 AI 中，自我报告的 binge drinking 与通过磁共振成像（MRI）测量的 VBI 之间的关联。与不 binge drinking 相比，多次 binge drinking 与脑沟扩大（β=0.360，95%CI[0.079, 0.641]）和脑室扩张（β=0.512，95%CI[0.174, 0.850]）有关。与以前的研究结果一致，这些观察到的关联表明，binge drinking 可能导致老年 AI 中的 VBI。确定 binge drinking 如何导致 VBI，可能会为减少神经风险和预防疾病提供可改变的健康行为。
Zotero 插件