Neurology Department, Peking University First Hospital, No.8 Xishiku Street, Beijing, 100034, China.
Neurology Department, University of Chinese Academy of Sciences Shenzhen Hospital (Guangming), No. 4253 Matian Street, Shenzhen, 518000, China.
BMC Neurol. 2021 Jun 26;21(1):244. doi: 10.1186/s12883-021-02287-5.
Cranial nerve involvement is not commonly encountered in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP); this is especially true for involvement of the hypoglossal nerve. Neither Beevor's sign nor its inverted form has previously been described in CIDP.
A 28-year-old man presented with distal-predominant limb weakness and numbness at the age of 18. A diagnosis of CIDP was made, which was confirmed by electrodiagnostic evidence of demyelination. He responded well to intravenous immunoglobulin and glucocorticoid treatment and achieved remission for 5 years. However, the same symptoms relapsed at the age of 28 and lasted for 10 months. On examination, in addition to limb sensory impairment and muscle weakness, mild bilateral facial paresis, tongue atrophy and fasciculations, and inverted Beevor's sign were also observed. A brief literature review of cranial nerve involvements in CIDP and Beevor's sign or its inverted form were also performed.
Cranial nerves may be affected in patients with CIDP. Facial palsy is most frequently present, while hypoglossal nerve involvement is rare. Inverted Beevor's sign can appear in CIDP patients.
颅神经受累在慢性炎症性脱髓鞘性多发性神经病（CIDP）中并不常见；舌下神经受累更是如此。在 CIDP 中，以前从未描述过 Beevor 征或其倒置形式。
一名 28 岁男性，18 岁时出现四肢远端为主的无力和麻木。诊断为 CIDP，电诊断证据提示脱髓鞘。他对静脉注射免疫球蛋白和糖皮质激素治疗反应良好，并在 5 年内缓解。然而，同样的症状在 28 岁时复发，持续了 10 个月。体格检查除四肢感觉障碍和肌无力外，还观察到轻度双侧面肌无力、舌萎缩和肌束震颤，以及 Beevor 征倒置。还对 CIDP 中的颅神经受累和 Beevor 征或其倒置形式进行了简短的文献复习。
CIDP 患者可能会出现颅神经受累。面神经麻痹最常见，而舌下神经受累罕见。CIDP 患者可出现 Beevor 征倒置。
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