瑞士职业人群肺癌死亡率：职业和非职业因素的影响。
Lung Cancer Mortality in the Swiss Working Population: The Effect of Occupational and Non-Occupational Factors.
机构信息
Department of Occupational and Environmental Health, Center for Primary Care and Public Health (unisanté), University of Lausanne, Lausanne, Switzerland (Mr Bovio, Dr Wild, and Pr Canu); INRS, Vandoeuvre Les Nancy Cedex, France (Dr Wild).
出版信息
J Occup Environ Med. 2021 Dec 1;63(12):1029-1036. doi: 10.1097/JOM.0000000000002302.
OBJECTIVE
To assess the effect of occupational exposures on lung cancer mortality in Switzerland after adjustment for non-occupational lung carcinogens.
METHODS
Using data on 4,351,383 Swiss residents, we used negative binomial regression to assess the effect occupation on lung cancer mortality between 1990 and 2014, accounting for socio-demographic factors, predicted probabilities of smoking and measured environmental radon exposure.
RESULTS
After adjustment, male machine operators and workers in mining, stone working and building materials manufacturing showed the highest risk. Women working in electrical engineering, electronics, watchmaking, vehicle construction and toolmaking, and transport occupations also remained at high risk. Radon exposure had no effect on lung cancer mortality, while smoking demonstrated a significant effect in both sexes.
CONCLUSIONS
The results suggest the presence of occupational exposures to lung carcinogens in addition to non-occupational factors.
目的
在调整非职业性肺癌致癌物因素后，评估瑞士职业暴露对肺癌死亡率的影响。
方法
利用瑞士 4351383 名居民的数据，我们使用负二项回归模型评估 1990 年至 2014 年期间职业对肺癌死亡率的影响，同时考虑了社会人口统计学因素、吸烟的预测概率和测量的环境氡暴露。
结果
调整后，男性机械操作人员和采矿、石材加工和建筑材料制造工人的风险最高。女性在电气工程、电子、制表、车辆制造和工具制造以及运输职业中也处于高风险。氡暴露对肺癌死亡率没有影响，而吸烟对两性都有显著影响。
结论
结果表明，除了非职业因素外，还存在职业性肺癌致癌物暴露。
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